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8.A.10.1.1
Slow voltage-dependent K+ channel auxiliary protein (β-subunit), MinK or K2NE1. KCNQ1-KCNE1 complexes may interact intermittently with the actin cytoskeleton via the C-terminal region (Mashanov et al., 2010; Coey et al., 2011).  The transmembrane region and the C-terminal cytoplasmic domains that abuts the KCNE1 TMS both interact with and regulate the KCNQ1 channel (Lvov et al. 2010; Zheng et al. 2010). Mutations in KCNE1 can cause Meniere's disease (Doi et al. 2005).

Accession Number:P15383
Protein Name:MinK aka KCNE1
Length:130
Molecular Weight:14699.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P15383
eggNOG: roNOG16464
RefSeq: NP_037105.1   
Entrez Gene ID: 25471   
Pfam: PF02060   
KEGG: rno:25471   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005251 F:delayed rectifier potassium channel activity
GO:0006813 P:potassium ion transport

References (6)

[1] “Cloning of a membrane protein that induces a slow voltage-gated potassium current.”  Takumi T.et.al.   3194754
[2] “Cloning and expression of the delayed-rectifier IsK channel from neonatal rat heart and diethylstilbestrol-primed rat uterus.”  Folander K.et.al.   2183220
[3] “Estrogen induction of a small, putative K+ channel mRNA in rat uterus.”  Pragnell M.et.al.   2344412
[4] “Characterization of gene organization and generation of heterogeneous mRNA species of rat ISK protein.”  Iwai M.et.al.   2229022
[5] “An amino acid mutation in a potassium channel that prevents inhibition by protein kinase C.”  Busch A.E.et.al.   1553557
[6] “Subunit composition of minK potassium channels.”  Wang K.-W.et.al.   7605639

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MALSNSTTVL PFLASLWQET DEPGGNMSAD LARRSQLRDD SKLEALYILM VLGFFGFFTL 
61:	GIMLSYIRSK KLEHSHDPFN VYIESDAWQE KGKALFQARV LESFRACYVI ENQAAVEQPA 
121:	THLPELKPLS