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8.A.10.2.1
K+ voltage-gated channel subfamily E member 2 (KCNE2) or minimum K+ channel-related peptide (MinK; MiRP1) (β-subunit) [associates with KCNH2/ERG1 and KCNQ1/KVLQT1 (McCrossan et al. 2009), as well as KCNQ2 and KCNQ3] (Eldstrom and Fedida, 2011Roepke et al., 2006). Regulated by PKCδ phosphorylation (O'Mahony et al., 2007).  A mutation (hERG T473P) in the transmembrane non-pore region  causes clinical manifestations of long QT syndrome (Liu et al. 2012).  Exhibits an array of functions in the heart, stomach, thyroid and choroid plexus. A variety of interconnected disease manifestations caused by KCNE2 disruption involve both excitable cells such as cardiomyocytes, and non-excitable, polarized epithelia (Abbott 2015).  It's secondary structure has been determined (Abbott et al. 2008). Deletion of the Kcne2 structural gene in mice and humans gives rise to impaired insulin secretion as well as type 2 diabetes mellitus (Lee et al. 2017).

Accession Number:Q9D808
Protein Name:KCNE2 aka MinK-related peptide 1
Length:123
Molecular Weight:14370.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q9D808
eggNOG: maNOG20159
HEGENOM: HBG125551
RefSeq: NP_598871.1   
Entrez Gene ID: 246133   
Pfam: PF02060   
KEGG: mmu:246133   

Gene Ontology

GO:0005249 F:voltage-gated potassium channel activity
GO:0006813 P:potassium ion transport

References (2)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATLANLTQT LEDAFKKIFI TYMDSWRRNT TAEEQALQAR VDAENFYYVI LYLMVMIGMF 
61:	SFIVVAILVS TVKSKRREHS QHPYHQYIVE DWQEKYKSQI LHLEDSKATI HENMGATGFT 
121:	VSP