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8.A.10.3.1
KCNE3 (β-subunit) constitutively opens outwardly rectifying KCNQ1 (Kv7.1) K+ channels by abolishing their voltage-dependent gating. KCNQ1/KCNE3 heteromers are present in basolateral membranes of intestinal and tracheal epithelial cells where they may facilitate transepithelial Cl- secretion (Preston et al., 2010).  Mutations cause Meniere's disease and tinnitus.  KCNE3 regulates Kv4.2 in spiral gangion neurons (Wang et al. 2014) and other voltage-gated ion channels (Kroncke et al. 2016). KCNE3 induces the constitutive activation of KCNQ1 in a process involving interactions in both sides of the membrane (Kroncke et al. 2016).

Accession Number:Q9WTW2
Protein Name:KCNE3 aka MinK-related peptide 2
Length:103
Molecular Weight:11720.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q9WTW2
HEGENOM: HBG269744
RefSeq: NP_065599.1   
Entrez Gene ID: 57442   
Pfam: PF02060   
KEGG: mmu:57442   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005249 F:voltage-gated potassium channel activity
GO:0006813 P:potassium ion transport

References (1)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	METSNGTETW YMSLHAVLKA LNTTLHSHLL CRPGPGPGPD NQTEDRRASL PGRNDNSYMY 
61:	ILFVMFLFAV TVGSLILGYT RSRKVDKRSD PYHVYIKNRV SMI