TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.102.1.1









Reticulon-like protein B6 of 253 aas and 4 TMSs, RTNLB6.

Eukaryota
Viridiplantae
RTNLB6 of Arabidopsis thaliana (Mouse-ear cress)
*8.A.102.1.2









Reticulon-3, Rtn3, of 964 aas and 3 - 4 TMSs at the C-terminus of the protein. May be involved in membrane trafficking in the early secretory pathway. Rtn3 inhibits BACE1 activity and amyloid precursor protein processing and may induce the caspase-8 cascade and apoptosis. May also favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress, and induces the formation of endoplasmic reticulum tubules (Yamamoto et al. 2014).

Eukaryota
Metazoa
Rtn3 of Mus musculus (Mouse)
*8.A.102.1.3









Reticulon-1 isoform X2, Rtn1, of 433 aas and 4 TMSs.

Eukaryota
Metazoa
Rtn1 of Apis mellifera
*8.A.102.1.4









Reticulon-like protein 1, RTN1 of 295 aas and 2 or 4 TMSs.

Eukaryota
Fungi
RTN1 of Saccharomyces cerevisiae (Baker's yeast)
*8.A.102.1.5









Reticulon-like protein of 216 aas and 4 TMSs.

Eukaryota
Dinophyceae
RTN protein of Pfiesteria piscicida (Dinoflagellate)
*8.A.102.1.6









Reticulon-3B, RTN3B, isoform X5 of 220 aas and 4 TMSs

Eukaryota
Metazoa
RTN3B protein of Oryzias latipes (Japanese rice fish;Japanese killifish)
*8.A.102.1.7









Reticulon-like protein B13, RTNLB13, of 206 aas and 4 TMSs, the smallest of the 21 reticulon-like proteins in A. thaliana (Chow et al. 2018).

Eukaryota
Viridiplantae
RTNBLB13 of Arabidopsis thaliana (Mouse-ear cress)
*8.A.102.1.8









Reticulon-like protein 2, RTN2, of 393 aas and 2, 3 or 4 TMSs.  Functioins together with Sey1 (TC# 1.N.5.1.6) as well as RTN1 (TC# 8.A.102.1.4), YOP1 of the DP1 family and LNP1 (P38878) to promote ER membrane fusion and reorganization (Hu and Rapoport 2016).

Eukaryota
Fungi
RTN2 of Saccharomyces cerevisiae (Baker's yeast)
*8.A.102.2.1









ER membrane reticulon-like protein of 202 aas and 4 TMSs

Eukaryota
Intramacronucleata
RTNL protein of Tetrahymena thermophila
*8.A.102.2.2









Uncharacterized protein of 180 aas and 4 TMSs.

Eukaryota
Apicomplexa
UP of Plasmodium malariae
*8.A.102.2.3









Putative reticulon domain-containing protein of 219 aas and 4 TMSs.

Eukaryota
Apicomplexa
Reticulon of Eimeria acervulina (Coccidian parasite)
*8.A.102.2.4









Uncharacterized protein of 188 aas and 4 TMSs.

Eukaryota
Apicomplexa
UP of Theileria equi
*8.A.102.2.5









Uncharacterized protein of 183 aas and 4 TMSs.

Eukaryota
Apicomplexa
UP of Cryptosporidium hominis