8.A.103. The Secretory Carrier-Associated Membrane Protein (SCAMP) Family
SCAMPs are in a family of highly related products of distinct genes, but SCAMP1, SCAMP2 and SCAMP3 largely colocalize at vesicle fusion sites (Singleton et al. 1997). The mammalian (Na+,K+/H+ exchanger, NHE7, resides chiefly in the trans-Golgi network (TGN) and post-Golgi vesicles where it contributes to organellar pH homeostasis (Lin et al. 2005). SCAMPs 1-4 are ubiquitously expressed and are major components of the eukaryotic cell surface recycling system. Castle and Castle 2005 found that different SCAMPs function along distinct pathways and behave like mobile trafficking machineries. In plants, SCAMPs influence accumulation of secondary cell wall components, including polysaccharides and phenolic compounds, in the woody tissues of tree stems (Obudulu et al. 2018).