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8.A.103.  The Secretory Carrier-Associated Membrane Protein (SCAMP) Family 

SCAMPs are highly related products of distinct genes, but SCAMP1, SCAMP2 and SCAMP3 largemly co0localize at vesicle fusion sites (Singleton et al. 1997). The mammalian (Na+,K+/H+ exchanger, NHE7, resides chiefly in the trans-Golgi network (TGN) and post-Golgi vesicles where it contributes to organellar pH homeostasis (Lin et al. 2005).  SCAMPs 1-4 are ubiquitously expressed and are major components of the eukaryotic cell surface recycling system.  Castle and Castle 2005 found that different SCAMPs function along distinct pathways and behave like mobile trafficking machineries.  In plants, SCAMP proteins  influence accumulation of secondary cell wall components, including polysaccharides and phenolic compounds, in the woody tissues of tree stems (Obudulu et al. 2018).

References associated with 8.a.103 family:

Castle, A. and D. Castle. (2005). Ubiquitously expressed secretory carrier membrane proteins (SCAMPs) 1-4 mark different pathways and exhibit limited constitutive trafficking to and from the cell surface. J Cell Sci 118: 3769-3780. 16105885

References associated with 8.A.103 family:

Fernández-Chacón, R. and T.C. Südhof. (2000). Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions. J. Neurosci. 20: 7941-7950. 11050114
Fjorback, A.W., H.K. Müller, J. Haase, M.K. Raarup, and O. Wiborg. (2011). Modulation of the dopamine transporter by interaction with Secretory Carrier Membrane Protein 2. Biochem. Biophys. Res. Commun. 406: 165-170. 21295544

References associated with 8.a.103 family:

Lin, P.J., W.P. Williams, Y. Luu, R.S. Molday, J. Orlowski, and M. Numata. (2005). Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. J Cell Sci 118: 1885-1897. 15840657

References associated with 8.A.103 family:

Liu, L., H. Liao, A. Castle, J. Zhang, J. Casanova, G. Szabo, and D. Castle. (2005). SCAMP2 interacts with Arf6 and phospholipase D1 and links their function to exocytotic fusion pore formation in PC12 cells. Mol. Biol. Cell 16: 4463-4472. 16030257

References associated with 8.a.103 family:

Liu, L., Z. Guo, Q. Tieu, A. Castle, and D. Castle. (2002). Role of secretory carrier membrane protein SCAMP2 in granule exocytosis. Mol. Biol. Cell 13: 4266-4278. 12475951

References associated with 8.A.103 family:

Müller, H.K., O. Wiborg, and J. Haase. (2006). Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2. J. Biol. Chem. 281: 28901-28909. 16870614

References associated with 8.a.103 family:

Obudulu, O., N. Mähler, T. Skotare, J. Bygdell, I.N. Abreu, M. Ahnlund, M. Latha Gandla, A. Petterle, T. Moritz, T.R. Hvidsten, L.J. Jönsson, G. Wingsle, J. Trygg, and H. Tuominen. (2018). A multi-omics approach reveals function of Secretory Carrier-Associated Membrane Proteins in wood formation of​ ​​Populus​​ ​trees. BMC Genomics 19: 11. 29298676
Singleton, D.R., T.T. Wu, and J.D. Castle. (1997). Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. J Cell Sci 110(Pt17): 2099-2107. 9378760