8.A.107. The V-type ATPase assembly factor, ATP6AP1 (ATP6AP1) Family
Atp6ap1b functions to localize the V-ATPase to the plasma membrane where it regulates proton flux and cytoplasmic pH in humans and zebrafish (Gokey et al. 2015). It forms a complex with ATP6AP2 which serves the same function (Guida et al. 2018). It has been given the designation of the Vacuolar ATP synthase subunit S1 (ATP6S1) family in the conserved domain database, CDD.