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8.A.11.1.1
The immunophilin-like prolyl-peptidyl isomerase TWISTED DWARF1 direct regulator of auxin efflux mediated by Pgp1 (3.A.1.201.5) and Pgp19 (3.A.1.201.6), Twd1 (shows significant sequence similarity with Toc64, 3.A.9.1.1)

Accession Number:Q9LDC0
Protein Name:Twd1
Length:365
Molecular Weight:41806.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q9LDC0
HEGENOM: HBG317613
RefSeq: NP_188801.2   
Entrez Gene ID: 821718   
Pfam: PF00254    PF07719   
KEGG: ath:AT3G21640   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005774 C:vacuolar membrane
GO:0005516 F:calmodulin binding
GO:0003755 F:peptidyl-prolyl cis-trans isomerase activity
GO:0009734 P:auxin mediated signaling pathway
GO:0048366 P:leaf development
GO:0006457 P:protein folding

References (7)

[1] “Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones.”  Sato S.et.al.   10819329
[2] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[3] “Characterization of Arabidopsis thaliana AtFKBP42 that is membrane-bound and interacts with Hsp90.”  Kamphausen T.et.al.   12410806
[4] “TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19.”  Geisler M.et.al.   14517332
[5] “Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters.”  Geisler M.et.al.   15133126
[6] “The ULTRACURVATA2 gene of Arabidopsis encodes an FK506-binding protein involved in auxin and brassinosteroid signaling.”  Perez-Perez J.M.et.al.   14730066
[7] “Crystal structure of a plant immunophilin domain involved in regulation of MDR-type ABC transporters.”  Weiergraeber O.H.et.al.   16364310
Structure:
2F4E   2IF4     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDESLEHQTQ THDQESEIVT EGSAVVHSEP SQEGNVPPKV DSEAEVLDEK VSKQIIKEGH 
61:	GSKPSKYSTC FLHYRAWTKN SQHKFEDTWH EQQPIELVLG KEKKELAGLA IGVASMKSGE 
121:	RALVHVGWEL AYGKEGNFSF PNVPPMADLL YEVEVIGFDE TKEGKARSDM TVEERIGAAD 
181:	RRKMDGNSLF KEEKLEEAMQ QYEMAIAYMG DDFMFQLYGK YQDMALAVKN PCHLNIAACL 
241:	IKLKRYDEAI GHCNIVLTEE EKNPKALFRR GKAKAELGQM DSARDDFRKA QKYAPDDKAI 
301:	RRELRALAEQ EKALYQKQKE MYKGIFKGKD EGGAKSKSLF WLIVLWQWFV SLFSRIFRRH 
361:	RVKAD