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8.A.114.1.1
Huntington-interacting Protein 14, HIP14, of 632 aas and 6 or more TMSS.  This protein has been suggested to be a Mg2+ transporter, but the evidence is equivocal (Schäffers et al. 2018).

Accession Number:Q8IUH5
Protein Name:Palmitoyltransferase ZDHHC17
Length:632
Molecular Weight:72640.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Genevestigator: Q8IUH5
eggNOG: prNOG06864
RefSeq: NP_056151.2   
Entrez Gene ID: 23390   
Pfam: PF00023    PF01529   
OMIM: 607799  gene
KEGG: hsa:23390   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0005515 F:protein binding
GO:0019706 F:protein-cysteine S-palmitoleyltransferase a...
GO:0004871 F:signal transducer activity
GO:0008270 F:zinc ion binding
GO:0042953 P:lipoprotein transport
GO:0043123 P:positive regulation of I-kappaB kinase/NF-k...

References (9)

[1] “HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.”  Singaraja R.R.et.al.   12393793
[2] “Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”  Nagase T.et.al.   10231032
[3] “Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.”  Matsuda A.et.al.   12761501
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Huntingtin interacts with a family of WW domain proteins.”  Faber P.W.et.al.   9700202
[7] “Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.”  Huang K.et.al.   15603740
[8] “Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase.”  Ducker C.E.et.al.   15489887
[9] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
Structure:
3EU9     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQREEGFNTK MADGPDEYDT EAGCVPLLHP EEIKPQSHYN HGYGEPLGRK THIDDYSTWD 
61:	IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN NRIDLVKYYI SKGAIVDQLG 
121:	GDLNSTPLHW ATRQGHLSMV VQLMKYGADP SLIDGEGCSC IHLAAQFGHT SIVAYLIAKG 
181:	QDVDMMDQNG MTPLMWAAYR THSVDPTRLL LTFNVSVNLG DKYHKNTALH WAVLAGNTTV 
241:	ISLLLEAGAN VDAQNIKGES ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE 
301:	FRQKVMLGTP FLVIWLVGFI ADLNIDSWLI KGLMYGGVWA TVQFLSKSFF DHSMHSALPL 
361:	GIYLATKFWM YVTWFFWFWN DLNFLFIHLP FLANSVALFY NFGKSWKSDP GIIKATEEQK 
421:	KKTIVELAET GSLDLSIFCS TCLIRKPVRS KHCGVCNRCI AKFDHHCPWV GNCVGAGNHR 
481:	YFMGYLFFLL FMICWMIYGC ISYWGLHCET TYTKDGFWTY ITQIATCSPW MFWMFLNSVF 
541:	HFMWVAVLLM CQMYQISCLG ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF 
601:	RCCGLFRPVI VDWTRQYTIE YDQISGSGYQ LV