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8.A.114.1.3
Golgi Ca2+ and Mg2+ transporting palmitoyltransferase GodZ (ZDHHC3) (also palmitoylates protein substrates; Hines et al., 2010; Goytain et al., 2008).  Residues 50-233 in this protein show 27% identity to residues 372-539 in 9.B.37.1.1.

Accession Number:Q8R173
Protein Name:Palmitoyltransferase ZDHHC3
Length:299
Molecular Weight:34041.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Genevestigator: Q8R173
HEGENOM: HBG716399
RefSeq: NP_081193.2   
Entrez Gene ID: 69035   
Pfam: PF01529   
KEGG: mmu:69035   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0016409 F:palmitoyltransferase activity
GO:0008270 F:zinc ion binding
GO:0018345 P:protein palmitoylation
GO:0006605 P:protein targeting

References (6)

[1] “Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain.”  Uemura T.et.al.   12163046
[2] “The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ.”  Keller C.A.et.al.   15229235
[3] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Identification of PSD-95 palmitoylating enzymes.”  Fukata M.et.al.   15603741
[6] “Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.”  Hayashi T.et.al.   16129400

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMLIPTHHFR DIERKPEYLQ PEKCAPPPFP GPAGAMWFIR DGCGIACAIV TWFLVLYAEF 
61:	VVLFVMLVPS RDYAYSIING IVFNLLAFLA LASHCRAMLT DPGAVPKGNA TKEFIESLQL 
121:	KPGQVVYKCP KCCSIKPDRA HHCSVCKRCI RKMDHHCPWV NNCVGENNQK YFVLFTMYIA 
181:	LISLHALIMV GFHFLHCFEE DWTKCSSFSP PTTVILLILL CFEALLFLIF TSVMFGTQVH 
241:	SICTDETGIE QLKKEERRWA KKTKWMNMKA VFGHPFSLGW ASPFATPDQG KADPYQYVV