TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.A.114.1.7
Golgi electrogenic, voltage-dependent, Mg2+-transporting palmitoyltransferase, Huntington-interacting protein, HIP14 (ZDHHC13) (Up-regulated with low [Mg2+]; Km =0.8 mM; regulated by autopalmitoylation) (Goytain et al., 2008).

Accession Number:Q8IUH4
Protein Name:Probable palmitoyltransferase ZDHHC13
Length:622
Molecular Weight:70861.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Genevestigator: Q8IUH4
eggNOG: prNOG13722
HEGENOM: HBG446337
RefSeq: NP_001001483.1    NP_061901.2   
Entrez Gene ID: 54503   
Pfam: PF00023    PF01529   
OMIM: 612815  gene
KEGG: hsa:54503   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008415 F:acyltransferase activity
GO:0004871 F:signal transducer activity
GO:0008270 F:zinc ion binding
GO:0043123 P:positive regulation of I-kappaB kinase/NF-k...

References (5)

[1] “HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.”  Singaraja R.R.et.al.   12393793
[2] “Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.”  Matsuda A.et.al.   12761501
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEGPGLGSQC RNHSHGPHPP GFGRYGICAH ENKELANARE ALPLIEDSSN CDIVKATQYG 
61:	IFERCKELVE AGYDVRQPDK ENVSLLHWAA INNRLDLVKF YISKGAVVDQ LGGDLNSTPL 
121:	HWAIRQGHLP MVILLLQHGA DPTLIDGEGF SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV 
181:	NGQTPLMLSA HKVIGPEPTG FLLKFNPSLN VVDKIHQNTP LHWAVAAGNV NAVDKLLEAG 
241:	SSLDIQNVKG ETPLDMALQN KNQLIIHMLK TEAKMRANQK FRLWRWLQKC ELFLLLMLSV 
301:	ITMWAIGYIL DFNSDSWLLK GCLLVTLFFL TSLFPRFLVG YKNLVYLPTA FLLSSVFWIF 
361:	MTWFILFFPD LAGAPFYFSF IFSIVAFLYF FYKTWATDPG FTKASEEEKK VNIITLAETG 
421:	SLDFRTFCTS CLIRKPLRSL HCHVCNCCVA RYDQHCLWTG RCIGFGNHHY YIFFLFFLSM 
481:	VCGWIIYGSF IYLSSHCATT FKEDGLWTYL NQIVACSPWV LYILMLATFH FSWSTFLLLN 
541:	QLFQIAFLGL TSHERISLQK QSKHMKQTLS LRKTPYNLGF MQNLADFFQC GCFGLVKPCV 
601:	VDWTSQYTMV FHPAREKVLR SV