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8.A.15.1.1
K+ channel auxiliary subunit (KChAP)

Accession Number:O70260
Protein Name:KChAP
Length:628
Molecular Weight:68364.00
Species:Rattus norvegicus (Rat) [10116]
Location1 / Topology2 / Orientation3: Nucleus speckle1
Substrate NONE

Cross database links:

Genevestigator: O70260
eggNOG: maNOG14247
RefSeq: NP_113972.2   
Entrez Gene ID: 83614   
Pfam: PF02891   
KEGG: rno:83614   

Gene Ontology

GO:0030425 C:dendrite
GO:0016607 C:nuclear speck
GO:0045202 C:synapse
GO:0003676 F:nucleic acid binding
GO:0015459 F:potassium channel regulator activity
GO:0008022 F:protein C-terminus binding
GO:0047485 F:protein N-terminus binding
GO:0008270 F:zinc ion binding
GO:0045449 P:regulation of transcription
GO:0009725 P:response to hormone stimulus
GO:0006350 P:transcription

References (3)

[1] “Cloning and expression of a novel K+ channel regulatory protein, KChAP.”  Wible B.A.et.al.   9565597
[2] “A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor.”  Levy C.et.al.   11709556
[3] “The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer.”  Rycyzyn M.A.et.al.   11997457

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA PSVQMKIKEL 
61:	YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP SPLASIPPTL LTPGTLLGPK REVDMHPPLP 
121:	QPVHPDVTMK PLPFYEVYGE LIRPTTLAST SSQRFEEAHF TFALTPQQLQ QILTSREVLP 
181:	GAKCDYTIQV QLRFCLCETS CPQEDYFPPN LFVKVNGKLC PLPGYLPPTK NGAEPKRPSR 
241:	PINITPLARL SATVPNTIVV NWSSEFGRNY SLSVYLVRQL TAGTLLQKLR AKGIRNPDHS 
301:	RALIKEKLTA DPDSEVATTS LRVSLMCPLG KMRLTVPCRA LTCAHLQSFD AALYLQMNEK 
361:	KPTWTCPVCD KKAPYESLII DGLFMEILNS CSDCDEIQFM EDGSWCPMKP KKEASEVCPP 
421:	PGYGLDGLQY SPVQEGNQSE NKKRVEVIDL TIESSSDEED LPPTKKHCPV TSAAIPALPG 
481:	SKGALTSGHQ PSSVLRSPAM GTLGSDFLSS LPLHEYPPAF PLGADIQGLD LFSFLQTESQ 
541:	HYSPSVITSL DEQDTLGHFF QFRGTPPHFL GPLAPTLGSS HRSATPAPAP GRVSSIVAPG 
601:	SSLREGHGGP LPSGPSLTGC RSDVISLD