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8.A.16.1.2
Calcium channel γ6-subunit, CACNG6.  Mediates inhibition of the low voltage-activated Cav3.1 channel by direct interaction involving a GxxxA motif in TMS1 (Lin et al. 2008).

Accession Number:Q9BXT2
Protein Name:CACNG6
Length:260
Molecular Weight:28129.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q9BXT2
eggNOG: prNOG19945
HEGENOM: HBG755243
RefSeq: NP_114103.2    NP_665813.1    NP_665814.1   
Entrez Gene ID: 59285   
OMIM: 606898  gene
KEGG: hsa:59285   

Gene Ontology

GO:0005891 C:voltage-gated calcium channel complex
GO:0005245 F:voltage-gated calcium channel activity
GO:0006816 P:calcium ion transport

References (3)

[1] “A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.”  Burgess D.L.et.al.   11170751
[2] “Calcium channel gamma subunits provide insights into the evolution of this gene family.”  Chu P.-J.et.al.   11738816
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMWSNFFLQE ENRRRGAAGR RRAHGQGRSG LTPEREGKVK LALLLAAVGA TLAVLSVGTE 
61:	FWVELNTYKA NGSAVCEAAH LGLWKACTKR LWQADVPVDR DTCGPAELPG EANCTYFKFF 
121:	TTGENARIFQ RTTKKEVNLA AAVIAVLGLA VMALGCLCII MVLSKGAEFL LRVGAVCFGL 
181:	SGLLLLVSLE VFRHSVRALL QRVSPEPPPA PRLTYEYSWS LGCGVGAGLI LLLGAGCFLL 
241:	LTLPSWPWGS LCPKRGHRAT