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8.A.16.2.1
Transmembrane AMPA receptor (AMPAR) regulatory proteins, also called voltage-dependent Ca2+ channel γ2 subunits, TARPγ2, CACNG2, gamma-2 or Stargazin; regulate Ca(v)2.2 (TC# 1.A.1.11.19) as well as GIRK (TC# 1.A.2.1.3) (Tselnicker and Dascal 2010). TARPγ2 and TARPγ7 (8.A.16.2.5) can substitute for each other (Yamazaki et al. 2015).  TARPs also enhance AMPAR function, altering ligand efficacy and receptor gating kinetics and shaping the postsynaptic response. Stargazin rescues gating deficiencies in AMPARs carrying mutations that destabilize the closed-cleft states of the ligand-binding domain (LBD), suggesting that stargazin stabilizes closed LBD states (MacLean et al. 2014).  For Ca2+-permeable AMPARs, stargazin enhances receptor function by increasing single-channel conductance, slowing channel gating, increasing calcium permeability, and relieving the voltage-dependent block by endogenous intracellular polyamines (McGee et al. 2015).  TARPs alter the conformations of pore-forming subunits and thereby affect antagonist interactions (Cokić and Stein 2008). By shifting the balance between AMPAR activation and desensitization, TARPs markedly facilitate the transduction of spillover-mediated synaptic signaling (Coombs et al. 2017).

Accession Number:Q9Y698
Protein Name:CACNG2
Length:323
Molecular Weight:35966.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q9Y698
eggNOG: prNOG14835
HEGENOM: HBG564649
RefSeq: NP_006069.1   
Entrez Gene ID: 10369   
Pfam: PF00822   
OMIM: 602911  gene
KEGG: hsa:10369   

Gene Ontology

GO:0030666 C:endocytic vesicle membrane
GO:0005891 C:voltage-gated calcium channel complex
GO:0005245 F:voltage-gated calcium channel activity
GO:0006816 P:calcium ion transport

References (4)

[1] “Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications.”  Black J.L. IIIet.al.   10221464
[2] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[3] “The DNA sequence of human chromosome 22.”  Dunham I.et.al.   10591208
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
Structure:
5kk2     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGLFDRGVQM LLTTVGAFAA FSLMTIAVGT DYWLYSRGVC KTKSVSENET SKKNEEVMTH 
61:	SGLWRTCCLE GNFKGLCKQI DHFPEDADYE ADTAEYFLRA VRASSIFPIL SVILLFMGGL 
121:	CIAASEFYKT RHNIILSAGI FFVSAGLSNI IGIIVYISAN AGDPSKSDSK KNSYSYGWSF 
181:	YFGALSFIIA EMVGVLAVHM FIDRHKQLRA TARATDYLQA SAITRIPSYR YRYQRRSRSS 
241:	SRSTEPSHSR DASPVGIKGF NTLPSTEISM YTLSRDPLKA ATTPTATYNS DRDNSFLQVH 
301:	NCIQKENKDS LHSNTANRRT TPV