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8.A.16.2.6
Voltage dependent Ca2+ channel γ8 subunit, CACNG8.  Interacts with calcineurin to regulate AMPA receptor phosphorylation and trafficking (Itakura et al. 2014).

Accession Number:Q8WXS5
Protein Name:CACNG8
Length:425
Molecular Weight:43481.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q8WXS5
eggNOG: maNOG21792
HEGENOM: HBG564649
RefSeq: NP_114101.4   
Entrez Gene ID: 59283   
Pfam: PF00822   
OMIM: 606900  gene
KEGG: hsa:59283   

Gene Ontology

GO:0030666 C:endocytic vesicle membrane
GO:0005891 C:voltage-gated calcium channel complex
GO:0005245 F:voltage-gated calcium channel activity
GO:0006816 P:calcium ion transport

References (2)

[1] “Calcium channel gamma subunits provide insights into the evolution of this gene family.”  Chu P.-J.et.al.   11738816
[2] “A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.”  Burgess D.L.et.al.   11170751

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MESLKRWNEE RGLWCEKGVQ VLLTTVGAFA AFGLMTIAIS TDYWLYTRAL ICNTTNLTAG 
61:	GDDGTPHRGG GGASEKKDPG GLTHSGLWRI CCLEGLKRGV CVKINHFPED TDYDHDSAEY 
121:	LLRVVRASSI FPILSAILLL LGGVCVAASR VYKSKRNIIL GAGILFVAAG LSNIIGVIVY 
181:	ISANAGEPGP KRDEEKKNHY SYGWSFYFGG LSFILAEVIG VLAVNIYIER SREAHCQSRS 
241:	DLLKAGGGAG GSGGSGPSAI LRLPSYRFRY RRRSRSSSRS SEPSPSRDAS PGGPGGPGFA 
301:	STDISMYTLS RDPSKGSVAA GLAGAGGGGG GAVGAFGGAA GGAGGGGGGG GGAGAERDRG 
361:	GSSGFLTLHN AFPKEAGGGV TVTVTRPPAP PAPRHPAPSA PAPGTLAKGA AASNTNTLNR 
421:	KTTPV