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8.A.16.2.7
The cataract-associated protein TMEM114 (222 aas) (Glycosylated) (Maher et al., 2011)

Accession Number:Q9D563
Protein Name:Transmembrane protein 114
Length:222
Molecular Weight:24388.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q9D563
eggNOG: NOG45634
HEGENOM: HBG715206
Entrez Gene ID: 74720   
KEGG: mmu:74720   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane

References (4)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation.”  Jamieson R.V.et.al.   17492639
[4] “The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members.”  Maher G.J.et.al.   21689651

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRVRLGALAG AAALSGALSF VLLAAAIGTD FWYIIDTERL ERSSQRMRDQ GPANRSQQEP 
61:	LSSHSGLWRT CRVQSSCTPL MNPFWQENVT VSDSSRQLLT MHGTFVILLP LSLIVMVFGG 
121:	MTGFLSFLLR AHLLLLLTGI LFLFGAMVTL TGISIYIAYS AVAFREAVCL LEERALLDQV 
181:	DIRFGWSLAL GWISFVSELL TGVVFLAAAR ALSLSQRQDQ AI