TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.A.16.5.3
Germ cell-specific gene-1-like (GSG1L) protein of 331 aas and 4 TMS in a 1 (N-terminal) + 3 TMS arrangement.  Calcium-permeable AMPA receptors (TC# 1.A.10) are specific for the neurotransmitter glutamate. They contribute to various forms of synaptic plasticity. Alterations in their expression or regulation are seen in a number of neurological conditions including stroke, motor neuron disease, and cocaine addiction. Several groups of auxiliary transmembrane proteins have been described that enhance the function and cell-surface expression of AMPARs, but GSG1L decreases channel conductance and calcium permeability while increasing polyamine-dependent rectification by diminishing outward current (McGee et al. 2015). GSG1L favors the AMPAR desensitized state, where channel closure is facilitated by large structural rearrangements in the AMPAR extracellular domain, with ligand-binding domain dimers losing their local 2-fold rotational symmetry. AMPAR auxiliary subunits probably share a modular architecture(Twomey et al. 2017).

Accession Number:Q6UXU4
Protein Name:Germ cell-specific gene 1-like protein
Length:331
Molecular Weight:36774.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKTSRRGRAL LAVALNLLAL LFATTAFLTT HWCQGTQRVP KPGCGQGGRA NCPNSGANAT 
61:	ANGTAAPAAA AAAATASGNG PPGGALYSWE TGDDRFLFRN FHTGIWYSCE EELSGLGEKC 
121:	RSFIDLAPAS EKGVLWLSVV SEVLYILLLV VGFSLMCLEL FHSSNVIDGL KLNAFAAVFT 
181:	VLSGLLGMVA HMMYTQVFQV TVSLGPEDWR PHSWDYGWSF CLAWGSFTCC MAASVTTLNS 
241:	YTKTVIEFRH KRKVFEQGYR EEPTFIDPEA IKYFRERMEK RDGSEEDFHL DCRHERYPAR 
301:	HQPHMADSWP RSSAQEAPEL NRQCWVLGHW V