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8.A.17.1.2
Sodium channel ß3 subunit (Morgan et al. 2000). It interacts with Na+ channel, Nav1.7 (Kanellopoulos et al. 2018).

Accession Number:Q9JK00
Protein Name:SCN3B aka SCNB3
Length:215
Molecular Weight:24799.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q9JK00
eggNOG: roNOG07893
RefSeq: NP_620797.1   
Entrez Gene ID: 245956   
Pfam: PF07686   
KEGG: rno:245956   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005272 F:sodium channel activity
GO:0005244 F:voltage-gated ion channel activity
GO:0019233 P:sensory perception of pain
GO:0006814 P:sodium ion transport

References (5)

[1] “Beta3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics.”  Morgan K.et.al.   10688874
[2] “Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits.”  Qu Y.et.al.   11922146
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain.”  Ratcliffe C.F.et.al.   11470829
[5] “Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na(v)1.8 voltage-gated sodium channel.”  Vijayaragavan K.et.al.   15178439

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPAFNRLLPL ASLVLIYWVR VCFPVCVEVP SETEAVQGNP MKLRCISCMK REEVEATTVV 
61:	EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL QDVSITVLNV TLNDSGLYTC 
121:	NVSREFEFEA HRPFVKTTRL IPLRVTEEAG EDFTSVVSEI MMYILLVFLT LWLFIEMIYC 
181:	YRKVSKAEEA AQENASDYLA IPSENKENSV VPVEE