TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.17.1.1









Sodium channel ß1 (β-1, beta-1) subunit.  This subunit can interact with and regulate the activity of the K+ channel, Kv10.1 of the KCNH family (TC# 1.A.1.2.17) as well as of Na+ channels (Kubota et al. 2017). Both beta1 and beta3 subunits regulate channel gating, expression, and pharmacology. Beta1 regulates NaV1.5 by modulating the 4th voltage-sensing domain, DIV-VSD, whereas beta3 alters channel kinetics mainly through the DIII-VSD interaction (Zhu et al. 2017).

Eukaryota
Metazoa
Navß1 (Navbeta1) of Homo sapiens (Q07699)
*8.A.17.1.2









Sodium channel beta3 (ß3)-subunit (Morgan et al. 2000). It interacts with Na+ channel, Nav1.7 (Kanellopoulos et al. 2018) as well as Nav1.5. Gating control of the cardiac sodium channel Nav1.5 by its beta3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain (Salvage et al. 2019).

 

Eukaryota
Metazoa
ß3 from Homo sapiens (Q9NY72)
*8.A.17.2.1









Sodium channel β2 subunit.  Distinctive biophysical properties of INa in atrial and ventricular myocytes can be attributed to inhomogeneous expression of NaVβ2 and NaVβ4 subunits, and atrial INa is more sensitive to inhibition by dronedarone (Chen et al. 2016).

Eukaryota
Metazoa
β2 from Homo sapiens (O60939)
*8.A.17.2.2









Sodium channel β4 subunit. The beta4 cis dimer contributes to the trans homophilic interaction of beta4 in cell-cell adhesion, and may exhibit increased association with the alpha subunit (Shimizu et al. 2017). Thus, the cis dimerization of beta4 probably affects alpha-beta4 complex formation.

Eukaryota
Metazoa
β4 from Homo sapiens (Q8IWT1)
*8.A.17.3.1









Immune-type receptor 4 of 280 aas and 2 TMSs.
Eukaryota
Metazoa
Immune-type receptor 4 of Ictalurus punctatus
*8.A.17.3.2









Uncharacterized protein of 265 aas and 2 or 3 potential TMSs, one near the N-terminus, and one near the C-terminus.  The protein shows two internal repeats, involving residues 54 - 110 and 186 - 249.

Eukaryota
Metazoa
UP of Danionella translucida
*8.A.17.3.3









Uncharacterized protein of 259 aas and 2 TMSs.

Eukaryota
Metazoa
UP of Pangasianodon hypophthalmus (striped catfish)
*8.A.17.3.4









Uncharacterized protein of 330 aas and 1 TMS near the C-terminus.

UP of Xiphophorus couchianus (Monterrey platyfish)
*8.A.17.3.5









T cell receptor alpha chain of 258 aas and 2 TMSs, N- and C-terminal.

Eukaryota
Metazoa
T cell receptor α of Stegastes partitus (bicolor damselfish)