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8.A.17.2.1
Sodium channel β2 subunit.  Distinctive biophysical properties of INa in atrial and ventricular myocytes can be attributed to inhomogeneous expression of NaVβ2 and NaVβ4 subunits, and atrial INa is more sensitive to inhibition by dronedarone (Chen et al. 2016).

Accession Number:O60939
Protein Name:SCN2B
Length:215
Molecular Weight:24326.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

Genevestigator: O60939
eggNOG: prNOG17903
HEGENOM: HBG716687
RefSeq: NP_004579.1   
Entrez Gene ID: 6327   
Pfam: PF07686   
Drugbank: Drugbank Link   
OMIM: 601327  gene
KEGG: hsa:6327   

Gene Ontology

GO:0001518 C:voltage-gated sodium channel complex
GO:0005248 F:voltage-gated sodium channel activity
GO:0006814 P:sodium ion transport
GO:0007268 P:synaptic transmission

References (4)

[1] “Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel.”  Eubanks J.et.al.   9295116
[2] “Exclusion of the SCN2B gene as candidate for CMT4B.”  Bolino A.et.al.   9887383
[3] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTVPATLNV LNGSDARLPC TFNSCYTVNH 
61:	KQFSLNWTYQ ECNNCSEEMF LQFRMKIINL KLERFQDRVE FSGNPSKYDV SVMLRNVQPE 
121:	DEGIYNCYIM NPPDRHRGHG KIHLQVLMEE PPERDSTVAV IVGASVGGFL AVVILVLMVV 
181:	KCVRRKKEQK LSTDDLKTEE EGKTDGEGNP DDGAK