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8.A.17.2.2
Sodium channel β4 subunit. The beta4 cis dimer contributes to the trans homophilic interaction of beta4 in cell-cell adhesion, and may exhibit increased association with the alpha subunit (Shimizu et al. 2017). Thus, the cis dimerization of beta4 probably affects alpha-beta4 complex formation.

Accession Number:Q8IWT1
Protein Name:SCN4B
Length:228
Molecular Weight:24969.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q8IWT1
eggNOG: prNOG20293
RefSeq: NP_001135820.1    NP_001135821.1    NP_777594.1   
Entrez Gene ID: 6330   
Pfam: PF07686   
Drugbank: Drugbank Link   
OMIM: 608256  gene
611819  phenotype
KEGG: hsa:6330   

Gene Ontology

GO:0001518 C:voltage-gated sodium channel complex
GO:0005248 F:voltage-gated sodium channel activity
GO:0006814 P:sodium ion transport

References (3)

[1] “Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.”  Yu F.H.et.al.   12930796
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome.”  Medeiros-Domingo A.et.al.   17592081
Structure:
4MZ2   4MZ3     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPGAGDGGKA PARWLGTGLL GLFLLPVTLS LEVSVGKATD IYAVNGTEIL LPCTFSSCFG 
61:	FEDLHFRWTY NSSDAFKILI EGTVKNEKSD PKVTLKDDDR ITLVGSTKEK MNNISIVLRD 
121:	LEFSDTGKYT CHVKNPKENN LQHHATIFLQ VVDRLEEVDN TVTLIILAVV GGVIGLLILI 
181:	LLIKKLIIFI LKKTREKKKE CLVSSSGNDN TENGLPGSKA EEKPPSKV