TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.A.18.2.1
Ca2+ channel, α2δ subunit 2, CACNA2D2 (Zhang et al. 2017).

Accession Number:Q9NY47
Protein Name:CACNA2D2
Length:1150
Molecular Weight:129876.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q9NY47
eggNOG: prNOG12135
RefSeq: NP_001005505.1    NP_006021.2   
Entrez Gene ID: 9254   
Pfam: PF02743    PF08473    PF00092    PF08399   
Drugbank: Drugbank Link   
OMIM: 607082  gene
KEGG: hsa:9254   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005262 F:calcium channel activity
GO:0046872 F:metal ion binding
GO:0005244 F:voltage-gated ion channel activity
GO:0006816 P:calcium ion transport

References (10)

[1] “Molecular diversity of the calcium channel alpha2delta subunit.”  Klugbauer N.et.al.   9880589
[2] “Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2).”  Gao B.et.al.   10766861
[3] “Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit.”  Hobom M.et.al.   10762351
[4] “Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.”  Nagase T.et.al.   9628581
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes.”  Gong H.C.et.al.   11687876
[7] “Calcium channel alpha2delta subunits: differential expression, function, and drug binding.”  Klugbauer N.et.al.   15000524
[8] “CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity.”  Carboni G.L.et.al.   12555074
[9] “Modulation of gating currents of the Ca(v)3.1 calcium channel by alpha 2 delta 2 and gamma 5 subunits.”  Lacinova L.et.al.   15111129
[10] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAVPARTCGA SRPGPARTAR PWPGCGPHPG PGTRRPTSGP PRPLWLLLPL LPLLAAPGAS 
61:	AYSFPQQHTM QHWARRLEQE VDGVMRIFGG VQQLREIYKD NRNLFEVQEN EPQKLVEKVA 
121:	GDIESLLDRK VQALKRLADA AENFQKAHRW QDNIKEEDIV YYDAKADAEL DDPESEDVER 
181:	GSKASTLRLD FIEDPNFKNK VNYSYAAVQI PTDIYKGSTV ILNELNWTEA LENVFMENRR 
241:	QDPTLLWQVF GSATGVTRYY PATPWRAPKK IDLYDVRRRP WYIQGASSPK DMVIIVDVSG 
301:	SVSGLTLKLM KTSVCEMLDT LSDDDYVNVA SFNEKAQPVS CFTHLVQANV RNKKVFKEAV 
361:	QGMVAKGTTG YKAGFEYAFD QLQNSNITRA NCNKMIMMFT DGGEDRVQDV FEKYNWPNRT 
421:	VRVFTFSVGQ HNYDVTPLQW MACANKGYYF EIPSIGAIRI NTQEYLDVLG RPMVLAGKEA 
481:	KQVQWTNVYE DALGLGLVVT GTLPVFNLTQ DGPGEKKNQL ILGVMGIDVA LNDIKRLTPN 
541:	YTLGANGYVF AIDLNGYVLL HPNLKPQTTN FREPVTLDFL DAELEDENKE EIRRSMIDGN 
601:	KGHKQIRTLV KSLDERYIDE VTRNYTWVPI RSTNYSLGLV LPPYSTFYLQ ANLSDQILQV 
661:	KLRISKLKDF EFLLPSSFES EGHVFIAPRE YCKDLNASDN NTEFLKNFIE LMEKVTPDSK 
721:	QCNNFLLHNL ILDTGITQQL VERVWRDQDL NTYSLLAVFA ATDGGITRVF PNKAAEDWTE 
781:	NPEPFNASFY RRSLDNHGYV FKPPHQDALL RPLELENDTV GILVSTAVEL SLGRRTLRPA 
841:	VVGVKLDLEA WAEKFKVLAS NRTHQDQPQK CGPNSHCEMD CEVNNEDLLC VLIDDGGFLV 
901:	LSNQNHQWDQ VGRFFSEVDA NLMLALYNNS FYTRKESYDY QAACAPQPPG NLGAAPRGVF 
961:	VPTVADFLNL AWWTSAAAWS LFQQLLYGLI YHSWFQADPA EAEGSPETRE SSCVMKQTQY 
1021:	YFGSVNASYN AIIDCGNCSR LFHAQRLTNT NLLFVVAEKP LCSQCEAGRL LQKETHSDGP 
1081:	EQCELVQRPR YRRGPHICFD YNATEDTSDC GRGASFPPSL GVLVSLQLLL LLGLPPRPQP 
1141:	QVLVHASRRL