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8.A.18.3.2
Voltage-gated Ca2+ channel α2δ subunit 4, CACNA2D4 (Kerov et al. 2018).

Accession Number:Q7Z3S7
Protein Name:Voltage-dependent calcium channel subunit alpha-2/delta-4
Length:1137
Molecular Weight:127938.00
Species: [9606]
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

Genevestigator: Q7Z3S7
eggNOG: prNOG08841
HEGENOM: HBG402807
RefSeq: NP_758952.4   
Entrez Gene ID: 93589   
Pfam: PF02743    PF00092    PF08399   
OMIM: 608171  gene
610478  phenotype
KEGG: hsa:93589   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005262 F:calcium channel activity
GO:0046872 F:metal ion binding
GO:0005244 F:voltage-gated ion channel activity
GO:0006816 P:calcium ion transport
GO:0050896 P:response to stimulus
GO:0007601 P:visual perception

References (5)

[1] “Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.”  Qin N.et.al.   12181424
[2] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[3] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy.”  Wycisk K.A.et.al.   17033974

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVCGCSALLP LPNPRPTMPA TPNFLANPSS SSRWIPLQPM PVAWAFVQKT SALLWLLLLG 
61:	TSLSPAWGQA KIPLETVKLW ADTFGGDLYN TVTKYSGSLL LQKKYKDVES SLKIEEVDGL 
121:	ELVRKFSEDM ENMLRRKVEA VQNLVEAAEE ADLNHEFNES LVFDYYNSVL INERDEKGNF 
181:	VELGAEFLLE SNAHFSNLPV NTSISSVQLP TNVYNKDPDI LNGVYMSEAL NAVFVENFQR 
241:	DPTLTWQYFG SATGFFRIYP GIKWTPDENG VITFDCRNRG WYIQAATSPK DIVILVDVSG 
301:	SMKGLRMTIA KHTITTILDT LGENDFINII AYNDYVHYIE PCFKGILVQA DRDNREHFKL 
361:	LVEELMVKGV GVVDQALREA FQILKQFQEA KQGSLCNQAI MLISDGAVED YEPVFEKYNW 
421:	PDCKVRVFTY LIGREVSFAD RMKWIACNNK GYYTQISTLA DTQENVMEYL HVLSRPMVIN 
481:	HDHDIIWTEA YMDSKLLSSQ AQSLTLLTTV AMPVFSKKNE TRSHGILLGV VGSDVALREL 
541:	MKLAPRYKLG VHGYAFLNTN NGYILSHPDL RPLYREGKKL KPKPNYNSVD LSEVEWEDQA 
601:	ESLRTAMINR ETGTLSMDVK VPMDKGKRVL FLTNDYFFTD ISDTPFSLGV VLSRGHGEYI 
661:	LLGNTSVEEG LHDLLHPDLA LAGDWIYCIT DIDPDHRKLS QLEAMIRFLT RKDPDLECDE 
721:	ELVREVLFDA VVTAPMEAYW TALALNMSEE SEHVVDMAFL GTRAGLLRSS LFVGSEKVSD 
781:	RKFLTPEDEA SVFTLDRFPL WYRQASEHPA GSFVFNLRWA EGPESAGEPM VVTASTAVAV 
841:	TVDKRTAIAA AAGVQMKLEF LQRKFWAATR QCSTVDGPCT QSCEDSDLDC FVIDNNGFIL 
901:	ISKRSRETGR FLGEVDGAVL TQLLSMGVFS QVTMYDYQAM CKPSSHHHSA AQPLVSPISA 
961:	FLTATRWLLQ ELVLFLLEWS VWGSWYDRGA EAKSVFHHSH KHKKQDPLQP CDTEYPVFVY 
1021:	QPAIREANGI VECGPCQKVF VVQQIPNSNL LLLVTDPTCD CSIFPPVLQE ATEVKYNASV 
1081:	KCDRMRSQKL RRRPDSCHAF HPEENAQDCG GASDTSASPP LLLLPVCAWG LLPQLLR