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Erythrocyte stomatin (Band 7) (Similar to Mechanosensory protein Mec2 (1.A.6.2.2))

Stomatin of Homo sapiens (P27105)

Podocin of 383 aas and 1 TMS.  Expressed exclusively in the slit-diaphragm of podocytes.  Mutations lead to steroid resistance followed by renal disease (Mulukala et al. 2016).

Podocin of Homo sapiens

Stomatin-like protein 3, STROML3 of 291 aas and 2 TMSs.  Functions in the regulation of ASIC channels in mobile vesicles in sensory neurons (Lapatsina et al. 2012).

STROML3 of Homo sapiens

Stomatin homologue. Cleavage of this protein by a protease encoded within the same operon as the stomatin has been reported to open an ion channel (Yokoyama and Matsui, 2005).

Stomatin homologue and its protease of Pyrococcus horikoshii
Stomatin homologue (O59180)
Protease (NP_143370)

QmcA protein (bacterial homologue) of 305 aas and 1 TMS (N-terminal).  May play a role in the quality control of integral membrane proteins. There is no evidence that it plays a role in transport.

QmcA of E. coli

Prohibitin, Wph, of 273 aas.

Prohibitn of Triticum aestivum (Wheat)

Signal peptide peptidase of 325 aas and 4 or 5 TMSs

Peptidase of Bdellovibrio exovorus

Modulator of FtsH protease, HflK, of 266 aas and 1 strong N-terminal TMS as well as as many as 3 or 4 additional less hydrophobic peaks that could be TMSs. It shows strong similarity to recognized stomatin proteins and  may function with an uncharacterized protein of 231 aas and 6 TMSs in a 2 + 2 + 2 TMS arrangement encoded by the gene adjacent to the hflK gene. This latter uncharacterized protein exhibits weak similarity to the second half of the NfeD protease (TC# 8.A.21.2.1). The protease domain of NfeD is in the first half.

Candidatus Thorarchaeota
HflK/ORF of Candidatus Thorarchaeota archaeon AB_25