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8.A.22.1.1
Voltage-dependent Ca2+ channel (VSCC) β1-subunit, CACNB1 of 597 aas.  VSCCs are composed of different subunits, α1, β, α2δ and γ, among which the cytosolic β subunit (Cavβ) controls the trafficking of the channel to the plasma membrane, its regulation and its gating properties. Many proteins interact with Cavβ, suggesting a multifunctional role of these proteins. Some of the newly assigned functions of Cavβ are independent of its role in the regulation of VGCC (Rima et al. 2016).

Accession Number:Q8R3Z5
Protein Name:CACNB1 aka CACNLB1
Length:597
Molecular Weight:65486.00
Species:Mus musculus (Mouse) [10090]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2 / Cytoplasmic side3
Substrate NONE

Cross database links:

Genevestigator: Q8R3Z5
RefSeq: NP_001152791.1    NP_001152792.1    NP_112450.1    NP_660099.2   
Entrez Gene ID: 12295   
Pfam: PF00625   
KEGG: mmu:12295   

Gene Ontology

GO:0016529 C:sarcoplasmic reticulum
GO:0030315 C:T-tubule
GO:0015270 F:dihydropyridine-sensitive calcium channel a...
GO:0008331 F:high voltage-gated calcium channel activity
GO:0005515 F:protein binding
GO:0006816 P:calcium ion transport
GO:0006612 P:protein targeting to membrane

References (5)

[1] “Structures of the murine genes for the beta1- and beta4-Subunits of the voltage-dependent calcium channel.”  Murakami M.et.al.   14500989
[2] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[3] “The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1.”  Anderson A.A.et.al.   16638807
[4] “Comprehensive identification of phosphorylation sites in postsynaptic density preparations.”  Trinidad J.C.et.al.   16452087
[5] “Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.”  Munton R.P.et.al.   17114649
Structure:
5gjv     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVQKSGMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA 
61:	ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSPGDEVP 
121:	VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQTLRQNR 
181:	LSSSKSGDNS SSSLGDVVTG TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK 
241:	GYEVTDMMQK ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA 
301:	EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK VLQRLIKSRG 
361:	KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH LAEYLEAYWK ATHPPSSTPP 
421:	NPLLNRTMAT AALAASPAPV SNLQGPYLAS GDQPLDRATG EHASVHEYPG ELGQPPGLYP 
481:	SNHPLGRAGT LRALSRQDTF DADTPGSRNS AYTEPGDSCV DMETDPSEGP GPGDPAGGGT 
541:	PPARQGSWED EEDYEEEMTD NRNRGRNKAR YCAEGGGPVL GRNKNELEGW GQGVYTR