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8.A.22.1.2
Voltage-gated Ca2+ channel β2-subunit, CACNB2

Accession Number:Q08289
Protein Name:CACNB2 aka CACNLB2 aka MYSB
Length:660
Molecular Weight:73581.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2 / Cytoplasmic side3
Substrate NONE

Cross database links:

Genevestigator: Q08289 Q08289
eggNOG: prNOG09479 prNOG09479
DIP: DIP-46117N DIP-46117N
RefSeq: NP_000715.2    NP_963864.1    NP_963865.2    NP_963884.2    NP_963887.2    NP_963890.2    NP_963891.1   
Entrez Gene ID: 783   
Pfam: PF00625    PF12052   
Drugbank: Drugbank Link   
OMIM: 600003  gene
611876  phenotype
KEGG: hsa:783   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0042383 C:sarcolemma
GO:0005891 C:voltage-gated calcium channel complex
GO:0005515 F:protein binding
GO:0005245 F:voltage-gated calcium channel activity
GO:0006816 P:calcium ion transport
GO:0007528 P:neuromuscular junction development
GO:0007411 P:axon guidance

References (13)

[1] “Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen.”  Rosenfeld M.R.et.al.   8494331
[2] “Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23.”  Taviaux S.et.al.   9254841
[3] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[4] “Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart.”  Yada H.et.al.   17525370
[5] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[6] “Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death.”  Antzelevitch C.et.al.   17224476
[7] “Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen.”  Rosenfeld M.R.et.al.   8494331
[8] “Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23.”  Taviaux S.et.al.   9254841
[9] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[11] “Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart.”  Yada H.et.al.   17525370
[12] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[13] “Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death.”  Antzelevitch C.et.al.   17224476

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVQRDMSKSP PTAAAAVAQE IQMELLENVA PAGALGAAAQ SYGKGARRKN RFKGSDGSTS 
61:	SDTTSNSFVR QGSADSYTSR PSDSDVSLEE DREAVRREAE RQAQAQLEKA KTKPVAFAVR 
121:	TNVSYSAAHE DDVPVPGMAI SFEAKDFLHV KEKFNNDWWI GRLVKEGCEI GFIPSPVKLE 
181:	NMRLQHEQRA KQGKFYSSKS GGNSSSSLGD IVPSSRKSTP PSSAIDIDAT GLDAEENDIP 
241:	ANHRSPKPSA NSVTSPHSKE KRMPFFKKTE HTPPYDVVPS MRPVVLVGPS LKGYEVTDMM 
301:	QKALFDFLKH RFEGRISITR VTADISLAKR SVLNNPSKHA IIERSNTRSS LAEVQSEIER 
361:	IFELARTLQL VVLDADTINH PAQLSKTSLA PIIVYVKISS PKVLQRLIKS RGKSQAKHLN 
421:	VQMVAADKLA QCPPELFDVI LDENQLEDAC EHLADYLEAY WKATHPPSSS LPNPLLSRTL 
481:	ATSSLPLSPT LASNSQGSQG DQRTDRSAPI RSASQAEEEP SVEPVKKSQH RSSSSAPHHN 
541:	HRSGTSRGLS RQETFDSETQ ESRDSAYVEP KEDYSHDHVD HYASHRDHNH RDETHGSSDH 
601:	RHRESRHRSR DVDREQDHNE CNKQRSRHKS KDRYCEKDGE VISKKRNEAG EWNRDVYIRQ