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8.A.22.1.3
Dihydropyridine-sensitive L-type, Ca2+ channel β3-subunit, CACNB3. Oligomerization of Cavβ subunits is required for Ca2+ channel activity (Lao et al., 2010).

Accession Number:P54284
Protein Name:CACNB3 aka CACNLB3
Length:484
Molecular Weight:54532.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2 / Cytoplasmic side3
Substrate NONE

Cross database links:

Genevestigator: P54284 P54284
eggNOG: prNOG13672 prNOG13672
HEGENOM: HBG445475 HBG445475
DIP: DIP-39138N DIP-39138N
RefSeq: NP_000716.2   
Entrez Gene ID: 784   
Pfam: PF00625    PF12052   
Drugbank: Drugbank Link   
OMIM: 601958  gene
KEGG: hsa:784    hsa:784   

Gene Ontology

GO:0005829 C:cytosol
GO:0005891 C:voltage-gated calcium channel complex
GO:0005515 F:protein binding
GO:0005245 F:voltage-gated calcium channel activity
GO:0006816 P:calcium ion transport
GO:0007411 P:axon guidance
GO:0051899 P:membrane depolarization
GO:0007268 P:synaptic transmission

References (13)

[1] “The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes.”  Yamada Y.et.al.   7557998
[2] “Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit.”  Collin T.et.al.   8119293
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.”  Qin N.et.al.   12181424
[6] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[7] “The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes.”  Yamada Y.et.al.   7557998
[8] “Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit.”  Collin T.et.al.   8119293
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[11] “Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.”  Qin N.et.al.   12181424
[12] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[13] “Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.”  Voss M.et.al.   19807924

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ QLERAKHKPV 
61:	AFAVRTNVSY CGVLDEECPV QGSGVNFEAK DFLHIKEKYS NDWWIGRLVK EGGDIAFIPS 
121:	PQRLESIRLK QEQKARRSGN PSSLSDIGNR RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV 
181:	VLVGPSLKGY EVTDMMQKAL FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER 
241:	SSARSSIAEV QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL 
301:	QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLEDACEHLA EYLEVYWRAT 
361:	HHPAPGPGLL GPPSAIPGLQ NQQLLGERGE EHSPLERDSL MPSDEASESS RQAWTGSSQR 
421:	SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA NGHDPQDRLL AQDSEHNHSD RNWQRNRPWP 
481:	KDSY