TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.23.1.1









Extracellular chaperone protein precursor, Basigin (BSG; CD147). Interacts with MCT1, 3 and 4 (TC# 2.A.1.13.1, 7 and 9, respectively) (Ovens et al., 2010; Halestrap 2012).  May play a role in cancer progression (Kendrick et al. 2016).

Eukaryota
Metazoa
Basigin precursor of Homo sapiens (P35613)
*8.A.23.1.2









Extracellular chaperone protein precursor, Embigin. Interacts with MCT2 (2.A.1.13.5) (Ovens et al., 2010; Halestrap 2012).

Eukaryota
Metazoa
Embigin of Homo sapiens (Q6PCB8)
*8.A.23.1.3









Potassium channel associated protein, contactin 2 (CNTN2).  Mutations are associated with autosomal recessive cortical myoclonic tremors and epilepsy (Stogmann et al. 2013).

Eukaryota
Metazoa
CNTN2 of Homo sapiens
*8.A.23.1.4









Canalicular bile acid transporter (C-BAT) ecto-ATPase (GP110)
Eukaryota
Metazoa
C-BAT (GP110) of Rattus norvegicus
*8.A.23.1.5









Hepatocyte cell adhesion molecule (CAM) precursor of 416 aas.  Important for interactions, trafficking and function of  ClC2 (CLC-2) in several tissues including the nervious system where it influences human leukodystrophies (Capdevila-Nortes et al. 2015).

Eukaryota
Metazoa
CAM of Homo sapiens
*8.A.23.1.6









Fibroblast growth factor receptor-like protein, FGFRL1, of 504 aas and 2 TMSs, one N-terminal and one C-terminal. It is capable of inducing syncytium formation (Steinberg et al. 2010).

Eukaryota
Metazoa
FGFRL-1 of Homo sapiens
*8.A.23.1.7









Fibroblast growth factor receptor 1, FGFR1, of822 aas and 2 TMSs, one N-terminal and one central.  FGFR1 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (Haenzi and Moon 2017).

FGFR1 of Homo sapiens
*8.A.23.1.8









Neuroplastin NptN of 398 aas (Beesley et al. 2014).  Important for targetting of certain transporters such as Xkr8 to the plasma membrane with which it, with basigin, forms a physical complex (Suzuki et al. 2016).

Eukaryota
Metazoa
NptN of Homo sapiens
*8.A.23.1.9









Fibroblast growth factor recpetor 4, FGFR4, of 802 aas and 2 - 4 TMSs.  Serves as the receptor for FGF23 for the activation of TRP6 (TC# 1.A.4.1.5). Binding activates the TRP6 channel for inorganic cation (including Ca2+) transport (Smith et al. 2017).

Eukaryota
Metazoa
FGFR4 of Homo sapiens
*8.A.23.1.10









Activated leukocyte cell adhesion molecule, ALCAM or CD166 antigen, of 583 aas and 2 TMSs, N- and C-terminal.  It is expressed on and in the cell membranes of various cells.  In the spinal cord dorsal horn (DH), the first gate for the sensory and pain transmission to the brain, ALCAM plays modulatory roles in the excitatory synaptic transmission and plasticity in the (rat) spinal DH (Park et al. 2017).

Eukaryota
Metazoa
ALCAM of Homo sapiens
*8.A.23.1.11









Interleukin 1 receptor of 569 aas and 2 TMSs, N-terminal and near the middle of the protein. It is the receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1, it associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. It binds ligands with comparable affinity, and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (Slack et al. 2000).

Eukaryota
Metazoa
IL-1R of Homo sapiens
*8.A.23.1.12









cSrc tyr kinase of 536 aas; regulates the Na+,K+-ATPase and connexin 43, probably by direct phosphorylation (Giepmans 2006).

Eukaryota
Metazoa
cSrc of Homo sapiens
*8.A.23.1.13









Epidermal growth factor receptor (EGFR) of 1426 aas and 2 or more TMSs.  Binds to four ligands: Spitz, Gurken, Vein and Argos, transducing signals through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions (Geiger et al. 2011).

Eukaryota
Metazoa
EGFR of Drosophila melanogaster (Fruit fly)
*8.A.23.1.14









Coxsackievirus and adenovirus receptor, CAR, of 365 aas and 2 TMSs, a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. It is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML, a transmembrane protein of the plasma membrane of leukocytes (Cohen et al. 2001). It's subcellular distribution has been studied (Ifie et al. 2018).

Eukaryota
Metazoa
CAR of Homo sapiens
*8.A.23.1.15









Ephrin type-B receptor 4 (EPHB4; EC:2.7.10.1). Alternative name(s): Hepatoma transmembrane kinase; Tyrosine-protein kinase, TYRO11.  It is a receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  It plays a role in postnatal blood vessel remodeling, morphogenesis and permeability (Erber et al. 2006; Martin-Almedina et al. 2016).

Eukaryota
Metazoa
EPHB4 of Homo sapiens