TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.24.1.1









NHERF1; NHERF-1; EBP50; SlcA3R1.  Na+/H+ exchanger regulatory factor (NHERF) proteins are a family of PSD-95/Discs-large/ZO-1 (PDZ)-scaffolding proteins, three of which (NHERFs 1-3) are localized to the brush border in kidney and intestinal epithelial cells. All NHERF proteins are involved in anchoring membrane proteins that contain PDZ recognition motifs to form multiprotein signaling complexes.  These NHERF proteins exhibit differential mobility in membranes (Yang et al. 2013).  Sites involved in binding to NPT2A (TC# 2.A.58.1.1) have been identified (Mamonova et al. 2015).

Eukaryota
Metazoa
SLC9A3R1 of Homo sapiens
*8.A.24.1.2









Solute carrier family 9, subfamily A (NHE3 cation proton antiporter 3 regulatory factor), member 3 regulator 2, SLC9A3R2 OR NHERF2 of 337 aas.  Binds erzin and affects dexamethasone stimulated NHE3 activity (Yang et al. 2015).  It also regulates several other transporters including CFTR (TC# 3.A.1.202.1) (Zhang et al. 2017).

Eukaryota
Metazoa
SLC9A3R2 of Homo sapiens
*8.A.24.1.3









Na+/H+ exchange regulatory factor (NHERF) or discs large homologue 4, PSD-95, PSD95, Dig4, Digh4, Dlg4 of 724 aas and 0 TMSs. Acts to stabilize and organize membrane targeting of multiple transmembrane proteins, including many clinically relevant drug transporters. These PDZ proteins are normally abundant at apical membranes, where they tether membrane-delimited transporters. NHERF expression is particularly high at the apical membrane in polarized tissue such as intestinal, hepatic, and renal epithelia, tissues (Walsh et al. 2015). DLG4 or PSD95 interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels and is required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. Moreover, DLG4 may reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. It also regulates the intracellular trafficking of ADR1B and controls AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density, keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.  This involves palmitoylation (Jeyifous et al. 2016).

Eukaryota
Metazoa
PSD95 of Homo sapiens
*8.A.24.1.4









Group II metabotropic glutamate receptor, mGluR2/3, interacting protein, Grip2, of 1043 aas.  May play a role as a localized scaffold for the assembly of multiprotein signaling complexes and as mediator of the trafficking of its binding partners at specific subcellular locations in neurons. In mutant mice, the mGluR2/3 agonist, LY379268, restores excitatory and inhibitory defects with similar efficiency as olanzapine in a two-hit schizophrenia mouse model (Engel et al. 2016).

Eukaryota
Metazoa
Grip2 of Rattus norvegicus (Rat)
*8.A.24.1.5









Synaptojanin-2 binding protein, Omp25, of 145 aas with a C-terminal TMS (C-tail-anchored mitochondrial outer membrane protein) (Setoguchi et al. 2006).

Eukaryota
Metazoa
Omp25 of Homo sapiens
*8.A.24.1.6









MAGI-2 or MAGI2 of 1455 aas. Scaffold protein at synaptic junctions, assembling neurotransmitter receptors and cell adhesion proteins (Wu et al. 2000). It is a multi-PDZ domain scaffolding protein that interacts with several different ligands in brain, including hyperpolarization-activated cation channels, beta1-adrenergic receptors, and NMDA receptors.  MAGI-2 is a strong candidate for linking TARP/AMPA receptor complexes to a wide range of other postsynaptic proteins and pathways (Deng et al. 2006).

 

Eukaryota
Metazoa
*8.A.24.1.7









Disc large homolog, 1DLG1 or SAP97, of 904 aas and 0 TMSs. Essential multidomain scaffolding protein required for normal development and lymphocyte activation (Xavier et al. 2004). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation and synaptogenesis. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 and Kv1.5 channels (El-Haou et al. 2009).

Eukaryota
Metazoa
DLG1 of Homo sapiens
*8.A.24.1.8









Stardust, Sdt, of 879 aas and 1 N-terminal TMS.  Sdt is a scaffolding protein that stabilizes the transmembrane protein, Crumbs (TC# 9.B.87.1.11), a conserved regulator of apical-basal epithelial polarity (Das and Knust 2017).

Eukaryota
Metazoa
Sdt of Drosophila melanogaster (Fruit fly)
*8.A.24.1.9









Zonula occludens-1 (ZO-1) (tight junction protein, TJP1) of 1748 aas. Regulates intestinal barrier function (Nicolodi and Sicuteri 1996), gap and tight junctions (Giepmans 2006; Yun et al. 2017), the organic cation/carnitine transporter, OCTN2 (Jurkiewicz et al. 2017), and CFTR (Ruan et al. 2014) among others.

Eukaryota
Metazoa
ZO-1 of Homo sapiens
*8.A.24.2.1









Syntenin-1, SDCBP of 298 aas and 1 C-terminal TMS. Also called syndecan binding protein-1, scaffold protein Pbp1, and melanoma differentiation-associated protein 9 (MDA-9) (Mitsou et al. 2017). Multifunctional adapter protein involved in a diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (Philley et al. 2016). Syndecans can regulate stretch-activated ion channels. The structure and function of the syndecanshave been reviewed (Mitsou et al. 2017).

and the ion channels are reviewed
Eukaryota
Metazoa
Syntenin-1 of Homo sapiens