TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.A.24.1.3
Na+/H+ exchange regulatory factor (NHERF) or discs large homologue 4, PSD-95, PSD95, Dig4, Digh4, Dlg4 of 724 aas and 0 TMSs. Acts to stabilize and organize membrane targeting of multiple transmembrane proteins, including many clinically relevant drug transporters. These PDZ proteins are normally abundant at apical membranes, where they tether membrane-delimited transporters. NHERF expression is particularly high at the apical membrane in polarized tissue such as intestinal, hepatic, and renal epithelia, tissues (Walsh et al. 2015). DLG4 or PSD95 interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels and is required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. Moreover, DLG4 may reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. It also regulates the intracellular trafficking of ADR1B and controls AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density, keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression.  This involves palmitoylation (Jeyifous et al. 2016).

Accession Number:P78352
Protein Name:Disks large homologue 4
Length:724
Molecular Weight:80495.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2
Substrate NONE

Cross database links:

Structure:
1KEF   2MES   3I4W   3K82   3ZRT     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MDCLCIVTTK KYRYQDEDTP PLEHSPAHLP NQANSPPVIV NTDTLEAPGY ELQVNGTEGE 
61:	MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV 
121:	NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN 
181:	QHIPGDNSIY VTKIIEGGAA HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY 
241:	LKVAKPSNAY LSDSYAPPDI TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD 
301:	LLGEEDIPRE PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL 
361:	SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT 
421:	ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS 
481:	ETDDIGFIPS KRRVERREWS RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL 
541:	GPTKDRANDD LLSEFPDKFG SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE 
601:	AGQYNSHLYG TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE 
661:	INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA 
721:	RERL