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8.A.24.1.4
Group II metabotropic glutamate receptor, mGluR2/3, interacting protein, Grip2, of 1043 aas.  May play a role as a localized scaffold for the assembly of multiprotein signaling complexes and as mediator of the trafficking of its binding partners at specific subcellular locations in neurons. In mutant mice, the mGluR2/3 agonist, LY379268, restores excitatory and inhibitory defects with similar efficiency as olanzapine in a two-hit schizophrenia mouse model (Engel et al. 2016).

Accession Number:Q9WTW1
Protein Name:Glutamate receptor-interacting protein 2
Length:1043
Molecular Weight:112488.00
Species:Rattus norvegicus (Rat) [10116]
Location1 / Topology2 / Orientation3: Membrane1 / Peripheral membrane protein2
Substrate NONE

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FASTA formatted sequence
1:	MLAVSLKWRL GVVRRRPKDD GPYSKGGKDT AGTDGALVCR RQSIPEEFRG ITMVELIKRE 
61:	GSTLGLTISG GTDKDGKPRV SNLRPGGLAA RSDLLNVGDY IRSVNGIRLT RLRHDEIITL 
121:	LKNVGERVVL EVEYELPPPA PENNPRIISK TVDVSLYKEG NSFGFVLRGG AHEDLHKSRP 
181:	LVLTYVRPGG PADREGSLKV GDRLLSIDGI PLHGASHATA IATLQQCSHE ALFQVEYDVA 
241:	TPDTVANASG PLVVEIAKTP GSALGISLTT GSHRNKPAIT IDRIKPASVV DRSGALHAGD 
301:	HILAIDGTST EHCSLVEATK LLASVTEKVR LEILPAPQSR RPLKPPEAVR IQRSEQLHHW 
361:	DPCVPSCHSP RPSHCRAPTW APGGQDQSRS VSSTPFSSPT MNPAFPCANA STLPRGPMSP 
421:	RTTAGRRRQR RKEHRSSLSL ASSTVGPGGQ IVHTETTEVV LCGDPLSGFG LQLQGGIFAT 
481:	ETLSSPPLVR FIEPDSPAER CGLLQVGDRV LAINGIATED GTMEEANQLL RDAALARKVV 
541:	LEIEFDVAES VIPSSGTFHV KLPKRRGVEL GITISSASRK RGEPLIISDI KKGSVAHRTG 
601:	TLEPGDKLLA IDNIRLDHCP MEYAVQILRQ CEDLVKLKIR KDEDNSDEQE SSGAVSYTVE 
661:	LKRYGGPLGI TISGTEEPFD PIIISGLTKR GLAERTGAIH VGDRILAINS VSLKGRPLSE 
721:	AIHLLQVAGE TVTLKIKKQL DRPLLPRQSG SLSEASDVDE DPPEALKGGL LTTHFSPAVP 
781:	SVDSAVESWG SSATEGGFGG SGSYTPQVAV RSVTPQEWRS SRLKSSPPPL EPRRTSYTPG 
841:	PTDESFPEEE EGDWEPPMSP APGPAREEGF WRVLGEALED LESCGQSELL RELEASIMTG 
901:	TVQSVAVDGR PGSRPWRRSR EVGTSPEDLQ ELLLPTPLEM HRVTLHKDPV RNDFGFSVSD 
961:	GLLEKGVYVH TVRIDGPAQH GGLQPFDRLL QVNHVRTRDF DCCLAVPLLA EAGDILELVV 
1021:	SRNPLAQSRR TPGAPGPSSP QMI