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8.A.24.2.1
Syntenin-1, SDCBP of 298 aas and 1 C-terminal TMS. Also called syndecan binding protein-1, scaffold protein Pbp1, and melanoma differentiation-associated protein 9 (MDA-9) (Mitsou et al. 2017). Multifunctional adapter protein involved in a diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (Philley et al. 2016). Syndecans can regulate stretch-activated ion channels. The structure and function of the syndecanshave been reviewed (Mitsou et al. 2017). and the ion channels are reviewed

Accession Number:O00560
Protein Name:Syntenin-1
Length:298
Molecular Weight:32444.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell junction1
Substrate NONE

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY PELSQYMGLS 
61:	LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND VGIRRAEIKQ GIREVILCKD 
121:	QDGKIGLRLK SIDNGIFVQL VQANSPASLV GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ 
181:	AFGEKITMTI RDRPFERTIT MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE 
241:	INGQNVIGLK DSQIADILST SGTVVTITIM PAFIFEHIIK RMAPSIMKSL MDHTIPEV