TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.25.1.1









Ezrin
Eukaryota
Metazoa
Ezrin of Mus musculus (P26040)
*8.A.25.1.2









The 4.1R protein of 864 aas.  Interacts with many membrane transporters, adhesins and receptors as well as cytoskelectal proteins to help organize the cell envelope (Baines et al. 2014).  For example, it interacts with the PMCA1b ATPase (TC# 3.A.3.2.25) (Diaz de Barboza et al. 2015).

Eukaryota
Metazoa
The 4.1R protein of Homo sapiens
*8.A.25.1.3









Merlin, Mer, EMR2, of 635 aas and 1 TMS. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway (Yu et al. 2010). Merlin and Expanded (Q07436; 1,427 aas) function synergistically to control proliferation by regulating the abundance, localization, and turnover of cell-surface receptors (Maitra et al. 2006).

 

Eukaryota
Metazoa
Merlin of Drosophila melanogaster (Fruit fly)
*8.A.25.1.4









Moesin, Moe, EMR1 of 578 aas and 1 TMS. Moesin is involved in connections of major cytoskeletal structures to the plasma membrane (McCartney and Fehon 1996). It plays a role in nuclear mRNA export together with the mRNA export factor PCID2 (Q9VTL1; 395 aas) and other messenger ribonucleoprotein (mRNP) particles (Kristó et al. 2017).

Eukaryota
Metazoa
Moesin of Drosophila melanogaster (Fruit fly)