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8.A.25.1.3
Merlin, Mer, EMR2, of 635 aas and 1 TMS. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway (Yu et al. 2010). Merlin and Expanded (Q07436; 1,427 aas) function synergistically to control proliferation by regulating the abundance, localization, and turnover of cell-surface receptors (Maitra et al. 2006).  

Accession Number:Q24564
Protein Name:Moesin/ezrin/radixin homolog 2
Length:635
Molecular Weight:74492.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell junction1
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPFGSKKNR SLSVRVSTFD SELEFKLEPR ASGQDLFDLV CRTIGLRESW YFGLQYVDTR 
61:	SNVSWLKMEK RVRDQRVELH ASNNVYVFSF YAKFFPENVS EELIQEITQH LFFLQVKQSI 
121:	LSMDIYCRPE ASVLLASYAV HVQYGPYDYE TYKDGMLAGG ELLPKGVTDQ YQMTPEMWEE 
181:	RIKTWYMDHE PMTRDEVEME YLKIAQDLDM YGVNYFPITN KNKTKLWLGV TSVGLNIYDE 
241:	RDKLTPKTTF QWNEIRHVSF DDKKFTIRLV DAKVSNFIFY SQDLHINKMI LDLCKGNHDL 
301:	YMRRRKPDTM EIQQMKAQAK EEKQRRQIER KKFIREKKLR EKAEHERYEL EKSMEHLQNE 
361:	MRMANDALRR SEETKELYFE KSRVNEEQMQ LTECKANHFK TEMDRLRERQ MKIEREKHDL 
421:	EKKIRDADFY VHQLTVENDK REAETEKLRK ELICAKMAER EATARLLEFL NSGRKSSTDS 
481:	LLTASSVSHA ANTASSMAAI STPSLITSSS TNDLETAGGA ELTTHSSHYL VQGDNSSGIS 
541:	DDFEPKEFIL TDNEMEQITN EMERNHLDYL RNSKQVQSQL QTLRSEIAPH KIEENQSNLD 
601:	ILSEAQIKAG ENKYSTLKKL KSGSTKARVA FFEEL