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8.A.27.1.2
The cell division control Cdc50 protein of 391 aas and 3 TMSs. It is an endosomal protein that regulates polarized cell growth (Misu et al. 2003).

Accession Number:P25656
Protein Name:Cdc50 aka YCR094W
Length:391
Molecular Weight:44982.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Late endosome membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

Genevestigator: P25656
eggNOG: fuNOG07491
HEGENOM: HBG525157
DIP: DIP-5138N
RefSeq: NP_010018.1   
Entrez Gene ID: 850456   
Pfam: PF03381   
KEGG: sce:YCR094W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0000299 C:integral to membrane of membrane fraction
GO:0031902 C:late endosome membrane
GO:0005802 C:trans-Golgi network
GO:0005515 F:protein binding
GO:0051666 P:actin cortical patch localization
GO:0006897 P:endocytosis
GO:0000080 P:G1 phase of mitotic cell cycle
GO:0045332 P:phospholipid translocation

References (6)

[1] “The cloning and characterization of the CDC50 gene family in Saccharomyces cerevisiae.”  Radji M.et.al.   11180453
[2] “The complete DNA sequence of yeast chromosome III.”  Oliver S.G.et.al.   1574125
[3] “Cdc50p, a conserved endosomal membrane protein, controls polarized growth in Saccharomyces cerevisiae.”  Misu K.et.al.   12589066
[4] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[5] “Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae.”  Saito K.et.al.   15090616
[6] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVSLFKRGKA PPLTKEGPTS KKPPNTAFRQ QRLKAWQPIL SPQSVLPLLI FVACIFTPIG 
61:	IGLIVSATKV QDLTIDYSHC DTKASTTAFE DIPKKYIKYH FKSKVENKPQ WRLTENENGE 
121:	QSCELQFEIP NDIKKSIFIY YKITNFYQNH RRYVQSFDTK QILGEPIKKD DLDTSCSPIR 
181:	SREDKIIYPC GLIANSMFND TFSQVLSGID DTEDYNLTNK HISWSIDRHR FKTTKYNASD 
241:	IVPPPNWMKK YPDGYTDENL PDIHTWEEFQ VWMRTAAFPK FYKLTLKNES ASLPKGKYQM 
301:	NIELNYPISL FGGTKSFVLT TNGAIGGRNM SLGVLYLIVA GLCALFGIIF LVKLIFQPRA 
361:	MGDHTYLNFD DEENEDYEDV HAENTTLREI L