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8.A.29.1.1
The Homer protein homologue1 (Ves1-1)

Accession Number:Q9Z2Y3
Protein Name:Homer protein homolog 1 aka Ves1-1
Length:366
Molecular Weight:41413.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate NONE

Cross database links:

Genevestigator: Q9Z2Y3
RefSeq: NP_036112.1    NP_671705.2    NP_687036.1   
Entrez Gene ID: 26556   
Pfam: PF00568   
KEGG: mmu:26556   

Gene Ontology

GO:0030054 C:cell junction
GO:0043034 C:costamere
GO:0005624 C:membrane fraction
GO:0014069 C:postsynaptic density
GO:0045211 C:postsynaptic membrane
GO:0030018 C:Z disc
GO:0005515 F:protein binding
GO:0032236 P:positive regulation of calcium ion transpor...
GO:0003009 P:skeletal muscle contraction
GO:0048741 P:skeletal muscle fiber development

References (6)

[1] “Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.”  Xiao B.et.al.   9808458
[2] “An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells.”  Saito H.et.al.   12176012
[3] “Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.”  Tu J.C.et.al.   9808459
[4] “Homer: a link between neural activity and glutamate receptor function.”  Xiao B.et.al.   10851183
[5] “Homer proteins and InsP(3) receptors co-localise in the longitudinal sarcoplasmic reticulum of skeletal muscle fibres.”  Salanova M.et.al.   12379179
[6] “Homer1c interacts with Hippi and protects striatal neurons from apoptosis.”  Sakamoto K.et.al.   17107665

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST 
61:	ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK 
121:	MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDVTQNS EPRAEPTQNA LPFPHSAGDR 
181:	TQALSHASSA ISKHWEAELA TLKGNNAKLT AALLESTANV KQWKQQLAAY QEEAERLHKR 
241:	VTELECVSSQ ANAVHSHKTE LNQTVQELEE TLKVKEEEIE RLKQEIDNAR ELQEQRDSLT 
301:	QKLQEVEIRN KDLEGQLSDL EQRLEKSQNE QEAFRSNLKT LLEILDGKIF ELTELRDNLA 
361:	KLLECS