TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.30.1.1









Nedd4-2 (1004 aas, 0 TMSs: Ubiquitin protein ligase, E3)/Nedd4 interacting protein-2 (311 aas; 3 TMSs: ww domain binding protein 5 (N4WBP5A)) (Zhou, et al., 2007)
Eukaryota
Metazoa
Nedd4-2/Nedd4-interacting protein-2 of Mus musculus
Nedd4-2
(Q8CFI0)
Nedd4-interacting protein-2
(Q91ZP6)
*8.A.30.1.2









E3 Ubiquitin protein ligase, NEDD4

Eukaryota
Metazoa
NEDD4 of Homo sapiens (P46934)
*8.A.30.1.3









Uncharacterized protein of 473aas and 3 TMSs

Eukaryota
Metazoa
Uncharacterized protein of Branchiostoma floridae (C3XWE5)
*8.A.30.1.4









E3 ubiquitin-protein ligase of 809 aas, RSP5, MDP1, NPI1. RSP5 is a component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other cell surface proteins including FUR4, MAL61, PMA1 and STE2 (Abe and Iida 2003; Pizzirusso and Chang 2004).

 

Eukaryota
Fungi
RSP5 of Sacchaomyces cerevisiae
*8.A.30.2.1









Metal homeostasis protein, Bsd2, of 321 aas and 2 or 3 TMSs. It is required for the homeostasis of heavy metal ions such as cadmium, cobalt and copper. It controls metal ion transport and prevents metal hyperaccumulation by negatively regulating the SMF1 and SMF2 metal transport systems (TC#s 2.A.55.1.1 and .1.2, respectively). Under manganese-replete conditions, Bsd2 facilitates trafficking of SMF1 and SMF2 metal transporters to the vacuole where they are degraded (Liu et al. 1997; Liu and Culotta 1999; Stimpson et al. 2006).

Eukaryota
Fungi
Bsd2 of Saccharomyces cerevisiae
*8.A.30.2.2









Related to metal homeostasis protein of 461aas and 3 putative TMSs

Eukaryota
Fungi
Metal homeostasis protein of Piriformospora indica (G4TIT2)
*8.A.30.2.3









Uncharacterized protein of 285aas and 2 putative TMSs

Eukaryota
Fungi
Uncharacterized protein of Ashbya gossypii (Q750M0)