8.A.31 The Ly-6 Neurotoxin-like Protein1 Precursor (Lynx1) Family
Lynx1 is a neuronal membrane protein (118 aas; 2 TMSs) related by fold to snake α-neurotoxins able to modulate nAChRs. Lynx 1 colocalizes with nAChRs on CNS neurons and physically associates with nAChRs. Single-channel recordings show that lynx1 promotes the largest of three current amplitudes elicited by ACh through α4β2 nAChRs and that lynx1 enhances desensitization. Macroscopic recordings quantified the enhancement of desensitization onset by lynx1 and further showed that it slows recovery from desensitization. Direct interaction of lynx1 with nAChRs results in a novel type of functional modulation and suggest that prototoxins may play important roles in vivo by modulating functional properties of their cognate CNS receptors (Ibanez-Tallon et al., 2002). The 3-d structure has been solved by NMR, and its action on the AChR has been studied (Lyukmanova et al. 2011).