TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.31.1.1









The Ly-6/neurotoxin-like protein1 precursor, Lynx1.  The NMR structure is available (Lyukmanova et al. 2011).

Eukaryota
Metazoa
Lynx1 of Homo sapiens
(Q9BZG9)
*8.A.31.1.2









Ly6/PLAUR domain-containing protein of 183 aas
Eukaryota
Metazoa
Ly6/PLAUR domain-containing protein of Homo sapiens
*8.A.31.1.3









The secreted Ly-6/uPAR-related protein, SLURP-1 of 103 aas and 1 or 2 TMSs. It is found in epithelium, sensory neurons and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation skin disease, Mal de Meleda. SLURP-1 is considered an autocrine/paracrine hormone that regulates growth and differentiation of keratinocytes and controls inflammation and malignant cell transformation. The antiproliferative activity of SLURP-1 is related to the 'metabotropic' signaling pathway through α7-nAChR, that activates intracellular signaling cascades without opening the receptor channel (Lyukmanova et al. 2016). Thus, SLURP-1 is an allosteric antogonist of the α7 nicotinic acetylcholine receptor.

Eukaryota
Metazoa
SLURP-1 of Homo sapiens
*8.A.31.1.4









Prostate and testis expressed  protein 4, PATE4 or SVS VII, is a heat labile phospholipid binding protein of 99 aas with 1 N-terminal TMS.  It enhances sperm motility and binds to calmodulin to inhibit calcium transport into spermatozoa. It may also modulate the function of nicotinic acetylcholine receptors (Luo et al. 2001).

Eukaryota
Metazoa
PATE4 of Mus musculus