TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.32.1.1









β-amyloid cleaving enzyme I of the pepsin/retropepsin-like aspartyl protease superfamily.  BACE1 amplified reconstituted M-currents, altered their voltage dependence, accelerated activation, and slowed deactivation by physical association with channel proteins in a beta-subunit-like fashion (Hessler et al. 2015).  BACE1 has a unique sulfur rich motif (M462xxxC466xxxM470xxxC474xxxC478) in its TMS which is characteristic for proteins involved in copper ion storage and transport. This motif promotes BACE1 trimerization and binding of copper ions in vitro. It conducts copper ions through a constricted, partially solvated, axial pore. A central P472 induced kink enables copper ions to alternate between different coordination sites including the prominent C466 and M470 (Bittner et al. 2018).

Eukaryota
Metazoa
BACE1 of Homo sapiens (P56817)
*8.A.32.1.2









β-secretase 2 of 518 aas, BACE2.

Eukaryota
Metazoa
beta-secretase 2 of Homo sapiens
*8.A.32.1.3









beta-secretase 2 isoform A of 518 aas and 1 or 2 TMSs.  It is responsible for the proteolytic processing of the amyloid precursor protein (APP) (Yan et al. 1999).

Eukaryota
Metazoa
β-secretase of Homo sapiens
*8.A.32.1.4









Pro-gastricsin, PGC of 388 aas.  It shows a more restricted substrate specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds (Hassan et al. 2010).  It is a member of the aspartic protease family, including pepsin and chymosin (Richter et al. 1998). It is involved in production of pro-antimicrobial substances in seminal plasma. The crystal structure shows that it is quite similar to that of porcine pepsinogen. The tertiary structure of PGC is bilobal with a large active-site cleft between the lobes. Two aspartyl residues in the center of the cleft, namely Asp32 and Asp215, function as catalytic residues (Hassan et al. 2010).

Eukaryota
Metazoa
Pgc of Homo sapiens
*8.A.32.1.5









Protein aspartic protease in guard cells of 653 aas and 2 TMSs, N- and C-terminal.

Eukaryota
Viridiplantae
Asp prtease of Brassica rapa (field mustard)