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8.A.34.1.1
Endophilin A1 (BAR-domain, SH3-domain containing GRB2-like protein 2 (Endophilin 1 or A1; SH3-domain protein 2A))

Accession Number:Q62420
Protein Name:Endophilin A1
Length:352
Molecular Weight:39955.00
Species:Mus musculus (Mouse) [10090]
Location1 / Topology2 / Orientation3: Cytoplasm1 / Peripheral membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q62420
DIP: DIP-30992N
RefSeq: NP_062408.2   
Entrez Gene ID: 20404   
Pfam: PF03114    PF00018   
KEGG: mmu:20404   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0016020 C:membrane
GO:0008289 F:lipid binding
GO:0005515 F:protein binding
GO:0006897 P:endocytosis

References (7)

[1] “Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.”  Sparks A.B.et.al.   9630982
[2] “Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene.”  Fehr C.et.al.   11978849
[3] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[4] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid.”  Schmidt A.et.al.   10490020
[7] “Crystal structure of the endophilin-A1 BAR domain.”  Weissenhorn W.et.al.   16023669
Structure:
1ZWW     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVAGLKKQF HKATQKVSEK VGGAEGTKLD DDFKEMERKV DVTSRAVMEI MTKTIEYLQP 
61:	NPASRAKLSM INTMSKIRGQ EKGPGYPQAE ALLAEAMLKF GRELGDDCNF GPALGEVGEA 
121:	MRELSEVKDS LDMEVKQNFI DPLQNLHDKD LREIQHHLKK LEGRRLDFDY KKKRQGKIPD 
181:	EELRQALEKF DESKEIAESS MFNLLEMDIE QVSQLSALVQ AQLEYHKQAV QILQQVTVRL 
241:	EERIRQASSQ PRREYQPKPR MSLEFATGDS TQPNGGLSHT GTPKPPGVQM DQPCCRALYD 
301:	FEPENEGELG FKEGDIITLT NQIDENWYEG MLHGQSGFFP INYVEILVAL PH