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8.A.37.1.1
Hepcidin

Accession Number:Q9EQ21
Protein Name:Hepcidin
Length:83
Molecular Weight:9352.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Genevestigator: Q9EQ21
eggNOG: NOG45549
HEGENOM: HBG126894
Entrez Gene ID: 84506   
Pfam: PF06446   
KEGG: mmu:84506   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005179 F:hormone activity
GO:0006879 P:cellular iron ion homeostasis
GO:0042742 P:defense response to bacterium
GO:0050832 P:defense response to fungus

References (4)

[1] “A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload.”  Pigeon C.et.al.   11113132
[2] “Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice.”  Nicolas G.et.al.   11447267
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload.”  Ilyin G.et.al.   12729891

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MALSTRTQAA CLLLLLLASL SSTTYLHQQM RQTTELQPLH GEESRADIAI PMQKRRKRDT 
61:	NFPICIFCCK CCNNSQCGIC CKT