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8.A.41 The Stretch-activated Calcium Channel Auxiliary Protein, Mid1 (Mid1) Family

The Mid1 protein in Saccharomyces cerevisiae forms a complex with the Cch1 calcium channel (TC# 1.A.1.11.10) and the Ecm7 protein (TC# 1.H.1.4.6).  The Mid1 protein appears to be essentially required for activity of Cch1 which is homologous to VIC family alpha subunits.  Mid1 proteins always have an N-terminal TMS, sometimes have a C-terminal TMS, and have been reported to have as many as 4 TMSs.  The Ecm7 protein is a homologue of claudins, some of which have been reported to have channel activity. 

References associated with 8.A.41 family:

Bormann, J. and P. Tudzynski. (2009). Deletion of Mid1, a putative stretch-activated calcium channel in Claviceps purpurea, affects vegetative growth, cell wall synthesis and virulence. Microbiology 155: 3922-3933. 19762439
Cavinder, B., A. Hamam, R.R. Lew, and F. Trail. (2011). Mid1, a mechanosensitive calcium ion channel, affects growth, development, and ascospore discharge in the filamentous fungus Gibberella zeae. Eukaryot. Cell. 10: 832-841. 21357477
Lew, R.R., Z. Abbas, M.I. Anderca, and S.J. Free. (2008). Phenotype of a mechanosensitive channel mutant, mid-1, in a filamentous fungus, Neurospora crassa. Eukaryot. Cell. 7: 647-655. 18296620
Liu, M. and A. Gelli. (2008). Elongation factor 3, EF3, associates with the calcium channel Cch1 and targets Cch1 to the plasma membrane in Cryptococcus neoformans. Eukaryot. Cell. 7: 1118-1126. 18503003