TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.5.1.1









K+ channel β1a chain.  Functions with Kv1.2 (Kvα1;KCNA2; TC# 1.A.1.2.10) to promote fast inactivation (Peters et al. 2009). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (Accili et al. 1998). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels Accelerates the closure of heteromeric channels formed by KCNA1, KCNA2, KCNA4, KCNA5 and KCNA6. Binds NADPH as is required for efficient down-regulation of potassium channel activity (Tipparaju et al. 2007). The protein has NADPH-dependent aldoketoreductase activity, and oxidation of the bound NADPH decreases N-type inactivation of channel activity.

Eukaryota
Metazoa
K+ channel subunit β1a of Homo sapiens (Q14722)
*8.A.5.1.2









The hyperkinetic (Hk) protein
Eukaryota
Metazoa
Hk of Drosophila melanogaster (Q24052)
*8.A.5.1.3









Chain A, β-subunit (x-ray structure available for this protein)
Eukaryota
Metazoa
β1a of Rattus norvegicus (P63144)
*8.A.5.1.4









General stress protein 69, GSP69.  There is no evidence that this protein functions to regulate a transport system in bacteria.

Bacteria
Firmicutes
GSP69 of Bacillus subtilis
*8.A.5.1.5









Aldo/keto (NADH) reductase of 346 aas, Tas. There is no evidence that this protein functions to regulate a transport system in bacteria.

Bacteria
Proteobacteria
Tas of E. coli
*8.A.5.1.6









Uncharacterized oxidoreductase of 342 aas, YajO.  There is no evidence that this protein functions to regulate a transport system in bacteria.

Bacteria
Proteobacteria
YajO of E. coli
*8.A.5.1.7









Oxidoreductase, YdhF, of 298 aas and 0 TMSs.  Not known to be involved in transport.

Bacteria
Proteobacteria
YdhF of E. coli