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8.A.5.1.1
K+ channel β1a chain.  Functions with Kv1.2 (Kvα1;KCNA2; TC# 1.A.1.2.10) to promote fast inactivation (Peters et al. 2009). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (Accili et al. 1998). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels Accelerates the closure of heteromeric channels formed by KCNA1, KCNA2, KCNA4, KCNA5 and KCNA6. Binds NADPH as is required for efficient down-regulation of potassium channel activity (Tipparaju et al. 2007). The protein has NADPH-dependent aldoketoreductase activity, and oxidation of the bound NADPH decreases N-type inactivation of channel activity.

Accession Number:Q14722
Protein Name:KCNAB1 aka KCNA1B
Length:419
Molecular Weight:46563.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate NONE

Cross database links:

Genevestigator: Q14722
eggNOG: prNOG18335
HEGENOM: HBG605727
RefSeq: NP_003462.2    NP_751891.1    NP_751892.1   
Entrez Gene ID: 7881   
Pfam: PF00248   
OMIM: 601141  gene
KEGG: hsa:7881   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0016021 C:integral to membrane
GO:0016491 F:oxidoreductase activity
GO:0015459 F:potassium channel regulator activity
GO:0005249 F:voltage-gated potassium channel activity
GO:0055114 P:oxidation reduction
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (8)

[1] “A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing.”  England S.K.et.al.   7499366
[2] “Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium.”  Majumder K.et.al.   7890032
[3] “Characterization of a voltage-gated K+ channel beta subunit expressed in human heart.”  England S.K.et.al.   7603988
[4] “Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product.”  Mccormack K.et.al.   7649300
[5] “Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B).”  Leicher T.et.al.   8938711
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits.”  Morales M.J.et.al.   7890764

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FASTA formatted sequence
1:	MLAARTGAAG SQISEENTKL RRQSGFSVAG KDKSPKKASE NAKDSSLSPS GESQLRARQL 
61:	ALLREVEMNW YLKLCDLSSE HTTVCTTGMP HRNLGKSGLR VSCLGLGTWV TFGGQISDEV 
121:	AERLMTIAYE SGVNLFDTAE VYAAGKAEVI LGSIIKKKGW RRSSLVITTK LYWGGKAETE 
181:	RGLSRKHIIE GLKGSLQRLQ LEYVDVVFAN RPDSNTPMEE IVRAMTHVIN QGMAMYWGTS 
241:	RWSAMEIMEA YSVARQFNMI PPVCEQAEYH LFQREKVEVQ LPELYHKIGV GAMTWSPLAC 
301:	GIISGKYGNG VPESSRASLK CYQWLKERIV SEEGRKQQNK LKDLSPIAER LGCTLPQLAV 
361:	AWCLRNEGVS SVLLGSSTPE QLIENLGAIQ VLPKMTSHVV NEIDNILRNK PYSKKDYRS