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8.A.5.1.3
Chain A, β-subunit (x-ray structure available for this protein)

Accession Number:P63144
Protein Name:Voltage-gated potassium channel subunit beta-1 aka Kcnab1 aka Kvb1
Length:401
Molecular Weight:44710.00
Species:Rattus norvegicus (Rat) [10116]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate NONE

Cross database links:

Genevestigator: P63144
eggNOG: maNOG12801
RefSeq: NP_058999.1   
Entrez Gene ID: 29737   
Pfam: PF00248   
KEGG: rno:29737   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0016021 C:integral to membrane
GO:0016491 F:oxidoreductase activity
GO:0005515 F:protein binding
GO:0005249 F:voltage-gated potassium channel activity
GO:0055114 P:oxidation reduction
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit.”  Rettig J.et.al.   8183366
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2.”  Gong J.et.al.   10477520
[4] “The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.”  Schulte U.et.al.   16504945

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQVSIACTEH NLKSRNGEDR LLSKQSSTAP NVVNAARAKF RTVAIIARSL GTFTPQHHIS 
61:	LKESTAKQTG MKYRNLGKSG LRVSCLGLGT WVTFGGQISD EVAERLMTIA YESGVNLFDT 
121:	AEVYAAGKAE VILGSIIKKK GWRRSSLVIT TKLYWGGKAE TERGLSRKHI IEGLKGSLQR 
181:	LQLEYVDVVF ANRPDSNTPM EEIVRAMTHV INQGMAMYWG TSRWSAMEIM EAYSVARQFN 
241:	MIPPVCEQAE YHLFQREKVE VQLPELYHKI GVGAMTWSPL ACGIISGKYG NGVPESSRAS 
301:	LKCYQWLKER IVSEEGRKQQ NKLKDLSPIA ERLGCTLPQL AVAWCLRNEG VSSVLLGSST 
361:	PEQLIENLGA IQVLPKMTSH VVNEIDNILR NKPYSKKDYR S