TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.51.1.1









The dipeptidyl aminopeptidase-like protein 6, β-subunit, Dpp6, DPPX-S or DPLP (865 aas) of the Kv4.2 K+ channel (TC# 1.A.1.2.5; Dougherty et al. 2009). DPPX-S destabilizes resting and intermediate states in the voltage-dependent activation pathway, which promotes the outward gating charge movement (Dougherty and Covarrubias 2006).

Eukaryota
Metazoa
  Dpp6 of Homo sapiens
*8.A.51.1.2









The inactive dipeptidyl peptidase or prolyl oligopeptidase, DPP10, DPRP-3, DPL2, DPPIV  or DPR3 of 798 aas and 1 N-terminal TMS. It has an N-terminal DPPIV_N domain and a C-terminal Abhydrolase domain. It is an inactivating modulator of Kv4 channels and the Kv1.4 channel (Kuo et al. 2017). DPP10 and KChIP2b (Q9NS61; TC# 5.B.1.2.2) both modulate Kv4.3 inactivation, but their primary effects are on different inactivation states. Thus DPP10 may be a general modulator of voltage-gated K+ channel inactivation (Kuo et al. 2017).

Eukaryota
Metazoa
DPP10 of Homo sapiens
*8.A.51.1.3









Dipeptide peptidease, DPP8 of 1452 aas.

Eukaryota
Metazoa
DPP8 of Trichinella patagoniensis
*8.A.51.1.4









Peptidase S9B dipeptidylpeptidase IV domain protein of 691 aas

Bacteria
Planctomycetes
Peptidase S9B of Rhodopirellula sp. SWK7