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8.A.64 The Phosphoinositide-interacting Protein (PIRT) Family 

PIRT is considered to be a regulatory subunit of various transient recptor potential (Trp) channels.  For example, TRPV1, a molecular sensor of noxious heat and capsaicin, is positively regulated by PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2) and other phosphoinositides, but not phosphatidylinositol (PI). Pirt and PIP2 also synergistically enhance TRPM8 channel activity by increasing the single channel conductance (Tang et al. 2015). Pirt is a molecular sensor of noxious heat and capsaicin. It positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2) and binds various phosphoinositides, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol. Moreover, Pirt is an endogenous regulator of the ATP-activated P2X3 channel (TC# 1.A.7.1.6) in bladder cells (Gao et al. 2015).

References associated with 8.A.64 family:

Gao, X.F., J.F. Feng, W. Wang, Z.H. Xiang, X.J. Liu, C. Zhu, Z.X. Tang, X.Z. Dong, and C. He. (2015). Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3. Nat Commun 6: 7650. 26151598
Hilton, J.K., T. Salehpour, N.J. Sisco, P. Rath, and W.D. Van Horn. (2018). Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels. J. Biol. Chem. [Epub: Ahead of Print] 29724821
Tang M., Wu GY., Dong XZ. and Tang ZX. (2016). Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance. Acta Pharmacol Sin. 37(1):98-104. 26657057