TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.68.1.1









Endosomal membrane protein 70, TMN2p (EMP70 superfamily) with an N-terminal hydrophilic domain and a 9 TMS C-terminal domain. The hydrophilic N-terminal domain is in the lumen of the cytoplasmic membrane.  Suggested to be a channel or small molecule transporter (Schimmöller et al. 1998).

Eukaryota
Fungi
TMN2p of Saccharomyces cerevisiae (E7NFP9)
*8.A.68.1.2









TMN7

Eukaryota
Viridiplantae
TMN7 of Arabidopsis thaliana (Q9LIC2)
*8.A.68.1.3









TM9SF4 protein (expressed in acidic vesicles of metastatic melanoma cells; not identified in normal cells) (1+2+2+2+2 TMS arrangement) (Lozupone et al. 2009; Lozupone et al. 2015)

Eukaryota
Metazoa
TM9SF4 of Homo sapiens (Q92544)
*8.A.68.1.4









Putative phagocytic receptor 1A (Phg1A). Required for cellular immunity via cell adhesion and phagoytosis (Bergeret et al. 2008). (possibly a member of the ion transporter (IT) superfamily, but not confirmed)

Eukaryota
Dictyosteliida
Phyg1A of Dictyostelium discoideum (Q55FP0)
*8.A.68.1.5









Syntaxin, SYP111.

Eukaryota
Viridiplantae
Syntaxin of Oryza sativa (Q84LF6)
*8.A.68.1.6









Transmembrane 9 superfamily member 2 (p76).  Possibly involved in spermatogenesis (Bonache et al. 2014).

Eukaryota
Metazoa
TM9SF2 of Homo sapiens
*8.A.68.1.7









Golgi endomembrane protein, EMP70 precursor (Gao et al. 2012).

Eukaryota
Viridiplantae
EMP70 of Arabidopsis thaliana
*8.A.68.1.8









TM9SF1 of 609 aas and 9 putative TMSs (Pruvot et al. 2010).

Eukaryota
Metazoa
TM9SF1 of Danio rerio (Zebrafish) (Brachydanio rerio)
*8.A.68.1.9









TM9SF2 of 659 aas and 9 TMSs.  Regulates (with TM9SF4) plasma membrane localization and signalling activity of the peptidoglycan recognizing protein, PGRP-LC (Perrin et al. 2015).

Eukaryota
Metazoa
TM9SF2 of Drosophila melanogaster (Fruit fly)
*8.A.68.1.10









TM9SF4 of 630 aas and 9 TMSs.  Regulates (with TM9SF2) plasma membrane localization and signalling activity of the peptidoglycan recognizing protein, PGRP-LC (Perrin et al. 2015).

Eukaryota
Metazoa
TM9SF4 of Drosophila melanogaster (Fruit fly)
*8.A.68.1.11









Uncharacterized TM9 family member of 730 aas and 10 TMSs.

Eukaryota
Fungi
UP of Tetrapisispora phaffii (Yeast) (Fabospora phaffii)
*8.A.68.1.12









TM9SF member of 650 aas and 10 TMSs.

Eukaryota
Intramacronucleata
TM9SF family member of Tetrahymena thermophila
*8.A.68.1.13









TM9SF1 of 606 aas and 9 or 10 TMSs. Functions in the regulation of autophagy (He et al. 2009).

Eukaryota
Metazoa
TM9SF1 of Homo sapiens