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8.A.68.1.4
Putative phagocytic receptor 1A (Phg1A). Required for cellular immunity via cell adhesion and phagoytosis (Bergeret et al. 2008). (possibly a member of the ion transporter (IT) superfamily, but not confirmed)

Accession Number:Q55FP0
Protein Name:Putative phagocytic receptor 1a
Length:641
Molecular Weight:73365.00
Species:Dictyostelium discoideum (Slime mold) [44689]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate NONE

Cross database links:

eggNOG: KOG1278 KOG1278
HEGENOM: HBG524073 HBG524073
Entrez Gene ID: 8616300   
Pfam: PF02990   
KEGG: ddi:DDB_G026744    ddi:DDB_G026744   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0004888 F:transmembrane receptor activity
GO:0008283 P:cell proliferation
GO:0031589 P:cell-substrate adhesion
GO:0042742 P:defense response to bacterium
GO:0006909 P:phagocytosis
GO:0033299 P:secretion of lysosomal enzymes
GO:0030587 P:sorocarp development

References (8)

[1] “Phg1p is a nine-transmembrane protein superfamily member involved in dictyostelium adhesion and phagocytosis.”  Cornillon S.et.al.   10944536
[2] “Synergistic control of cellular adhesion by transmembrane 9 proteins.”  Benghezal M.et.al.   12857872
[3] “The genome of the social amoeba Dictyostelium discoideum.”  Eichinger L.et.al.   15875012
[4] “Specific host genes required for the killing of Klebsiella bacteria by phagocytes.”  Benghezal M.et.al.   16367873
[5] “Phg1p is a nine-transmembrane protein superfamily member involved in dictyostelium adhesion and phagocytosis.”  Cornillon S.et.al.   10944536
[6] “Synergistic control of cellular adhesion by transmembrane 9 proteins.”  Benghezal M.et.al.   12857872
[7] “The genome of the social amoeba Dictyostelium discoideum.”  Eichinger L.et.al.   15875012
[8] “Specific host genes required for the killing of Klebsiella bacteria by phagocytes.”  Benghezal M.et.al.   16367873

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKINKKQIVF FILFSIFLNH VNGIFYLPGM IPHDFAQGEE GAIKVNKITS VHTQIPYKYY 
61:	QLPGVCQPKE GIIDDTENLG EILLGDRIEN SDYTFNFLTD GGKCKVINSE SCSPIIKKED 
121:	LKVLEDRIQN QYRVHWLLDG LPVRQTGRLA SDPGFDLGFM TLAEGQTVAT AEKYLNNHLE 
181:	ITIFYHSNPT DNTSRIVGFE IFPTSRQYKK VENWKGDTGD DCPQYGENFE QLSVSVKEGE 
241:	DQERFVLWTY EVKYTPSPVL WNKRWDIYFE SNDNSVHWFS ILNSLMIVFI LTVMVAMIII 
301:	RTLKKDIRRY TSIDTSEDRD SQEETGWKMI HGDVFRPPSH PMLLSVCIGS GVQIFSMTLI 
361:	TMIFAVLGFL SPANIGGLAT ALIVLFVLSA MFAGYFSTRV FTIFKGRNWK KNTIYTALSM 
421:	PGIIFGIFFF VNMFLRGAKS SAAVPFGTFA SIIAMWFGIS VPLVFLGSYF ASKKPVPEDP 
481:	VRTNQIPRQV PDQIWYMNPY LSILMGGILP FGAVFIELHF ILTSLWDNQF YYIFGFLFIV 
541:	LMILIVTSAE ISIVMCYFQL CAEDHHWWWR SFLTAGSSSL YMFIYSVSFF RYLGITKFIS 
601:	SLLDFSYSFI MSLAFAALTG TIGFYSCYFL VRKIYSSIHI N