8.A.71 The RIC3 Protein (RIC3) Family
The resistance to Inhibitors of Cholinesterase (RIC-3) has been shown to interfere with assembly and functional maturation of ligand-gated ion channels (LGICs). The RIC3 protein of humans is 369 aas with 2 TMSs. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. It also promotes functional expression of homomeric serotoninergic 5-HT3 receptors and heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4 (Halevi et al. 2003). The direct interaction of serotonin type 3A homopentamers (5-HT3A ) with RIC-3 requires the intracellular domain (ICD) of this pLGIC (Nishtala et al. 2016).